基本信息:
- 专利标题： INTERPENETRATING POLYMER NETWORK HYDROGEL CORNEAL PROSTHESIS
- 专利标题（中）：互聚聚合物网络水力发电机
- 申请号：PCT/US2006/047878 申请日：2006-12-14
- 公开(公告)号：WO2007133266A2 公开(公告)日：2007-11-22
- 发明人： MYUNG, David , TA, Christopher , FRANK, Curtis, W. , KOH, Won-gun , NOOLANDI, Jaan
- 申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MYUNG, David , TA, Christopher , FRANK, Curtis, W. , KOH, Won-gun , NOOLANDI, Jaan
- 申请人地址： 1705 El Camino Real Palo Alto, CA 94306-1106 US
- 专利权人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY,MYUNG, David,TA, Christopher,FRANK, Curtis, W.,KOH, Won-gun,NOOLANDI, Jaan
- 当前专利权人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY,MYUNG, David,TA, Christopher,FRANK, Curtis, W.,KOH, Won-gun,NOOLANDI, Jaan
- 当前专利权人地址： 1705 El Camino Real Palo Alto, CA 94306-1106 US
- 代理机构： McFARLANE, Thomas, J. et al.
- 优先权： US11/409,218 20060420; US60/843,942 20060911; US11/639,049 20061213
- 主分类号： H01Q1/38
- IPC分类号： H01Q1/38
摘要：
The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要（中）：
本发明提供具有高葡萄糖和透氧性，强度，含水量和耐蛋白质吸附性的材料。 这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。 第一个聚合物网络是基于亲水的遥爪大分子单体。 第二聚合物网络基于亲水性单体。 在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。 在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。 任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。 该材料设计用作角膜假体。
IPC结构图谱:
| H | 电学 |
| --H01 | 基本电气元件 |
| ----H01Q | 天线 |
| ------H01Q1/00 | 天线零部件或与天线结合的装置 |
| --------H01Q1/08 | .折叠天线或其附件的装置 |
| ----------H01Q1/38 | ..在绝缘支架上由导电层构成的 |