发明申请
WO2007103881A2 METHODS AND APPARATUS FOR TREATING CONGESTIVE HEART FAILURE, HYPERTENSION, ACUTE MYOCARDIAL INFARCTION, END-STAGE RENAL DISEASE, AND/OR CONTRAST NEPHROPATHY
审中-公开
基本信息:
- 专利标题： METHODS AND APPARATUS FOR TREATING CONGESTIVE HEART FAILURE, HYPERTENSION, ACUTE MYOCARDIAL INFARCTION, END-STAGE RENAL DISEASE, AND/OR CONTRAST NEPHROPATHY
- 专利标题（中）：治疗顽固性心脏衰竭，高血压，急性心肌梗死，终末期肾病，和/或对比非恶性脑病的方法和装置
- 申请号：PCT/US2007063324 申请日：2007-03-05
- 公开(公告)号：WO2007103881A2 公开(公告)日：2007-09-13
- 发明人： DEMARAIS DENISE , GIFFORD HANSON , DEEM MARK , SUTTON DOUGLAS , LEVIN HOWARD R , GELFAND MARK
- 申请人： ARDIAN INC , DEMARAIS DENISE , GIFFORD HANSON , DEEM MARK , SUTTON DOUGLAS , LEVIN HOWARD R , GELFAND MARK
- 专利权人： ARDIAN INC,DEMARAIS DENISE,GIFFORD HANSON,DEEM MARK,SUTTON DOUGLAS,LEVIN HOWARD R,GELFAND MARK
- 当前专利权人： ARDIAN INC,DEMARAIS DENISE,GIFFORD HANSON,DEEM MARK,SUTTON DOUGLAS,LEVIN HOWARD R,GELFAND MARK
- 优先权： US36897106 2006-03-06; US36880906 2006-03-06; US36894906 2006-03-06; US36857706 2006-03-06; US36855306 2006-03-06; US12976505 2005-05-13; US13392505 2005-05-20; US18956305 2005-07-25; US26693305 2005-11-04; US37019002 2002-04-08; US40866503 2003-04-08; US41557502 2002-10-03; US44297003 2003-01-29; US61625404 2004-10-05; US62479304 2004-11-02; US90019904 2004-07-28
- 主分类号： A61N1/18
- IPC分类号： A61N1/18 ; A61N1/40
摘要：
Methods and apparatus are provided for treating congestive heart failure, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要（中）：
提供了用于经由脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗充血性心力衰竭的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合， 凋亡的坏死和/或诱导，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。 在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。 在一些实施方案中，这种神经调节以双向方式进行。 与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61N | 电疗；磁疗；放射疗；超声波疗 |
| ------A61N1/00 | 电疗法；其所用的线路 |
| --------A61N1/18 | .通过接触电极施加电流 |