基本信息:
- 专利标题： CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS
- 专利标题（中）：环烷基胺作为单胺再生抑制剂
- 申请号：PCT/US2007000376 申请日：2007-01-05
- 公开(公告)号：WO2007081857A3 公开(公告)日：2007-11-08
- 发明人： SHAO LIMING , WANG FENGJIANG , MALCOLM SCOTT CHRISTOPHER , HEWITT MICHAEL CHARLES , BUSH LARRY R , MA JIANGUO , VARNEY MARK A , CAMPBELL UNA , ENGEL SHARON RAE , HARDY LARRY WENDELL , KOCH PATRICK , CAMPBELL JOHN E
- 申请人： SEPRACOR INC , SHAO LIMING , WANG FENGJIANG , MALCOLM SCOTT CHRISTOPHER , HEWITT MICHAEL CHARLES , BUSH LARRY R , MA JIANGUO , VARNEY MARK A , CAMPBELL UNA , ENGEL SHARON RAE , HARDY LARRY WENDELL , KOCH PATRICK , CAMPBELL JOHN E
- 专利权人： SEPRACOR INC,SHAO LIMING,WANG FENGJIANG,MALCOLM SCOTT CHRISTOPHER,HEWITT MICHAEL CHARLES,BUSH LARRY R,MA JIANGUO,VARNEY MARK A,CAMPBELL UNA,ENGEL SHARON RAE,HARDY LARRY WENDELL,KOCH PATRICK,CAMPBELL JOHN E
- 当前专利权人： SEPRACOR INC,SHAO LIMING,WANG FENGJIANG,MALCOLM SCOTT CHRISTOPHER,HEWITT MICHAEL CHARLES,BUSH LARRY R,MA JIANGUO,VARNEY MARK A,CAMPBELL UNA,ENGEL SHARON RAE,HARDY LARRY WENDELL,KOCH PATRICK,CAMPBELL JOHN E
- 优先权： US75655006 2006-01-06
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; A61K31/335
摘要：
The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
摘要（中）：
本发明涉及新的环己胺衍生物及其在治疗和/或预防中枢神经系统（CNS）疾病如抑郁症，焦虑症，精神分裂症和睡眠障碍中的用途以及它们的合成方法。 本发明还涉及含有本发明化合物的药物组合物，以及从突触间隙抑制内源性单胺（例如多巴胺，5-羟色胺和去甲肾上腺素）的再摄取的方法以及调节一种或多种单胺转运体的方法。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/381 | ...五元环的 |