基本信息:
- 专利标题： MONOCLONAL ANTIBODIES AGAINST ORTHOPOXVIRUSES
- 专利标题（中）：抗逆转录病毒的单克隆抗体
- 申请号：PCT/US2006/048832 申请日：2006-12-22
- 公开(公告)号：WO2007075914A2 公开(公告)日：2007-07-05
- 发明人： CHEN, Zhaochun , EARL, Patricia , MOSS, Bernard , EMERSON, Suzanne, U. , PURCELL, Robert, H.
- 申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , CHEN, Zhaochun , EARL, Patricia , MOSS, Bernard , EMERSON, Suzanne, U. , PURCELL, Robert, H.
- 申请人地址： National Institutes of Health Office of Technology Transfer, 6011 Executive Blvd., Suite 325, Rockville, MD 20852-3804 US
- 专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,CHEN, Zhaochun,EARL, Patricia,MOSS, Bernard,EMERSON, Suzanne, U.,PURCELL, Robert, H.
- 当前专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,CHEN, Zhaochun,EARL, Patricia,MOSS, Bernard,EMERSON, Suzanne, U.,PURCELL, Robert, H.
- 当前专利权人地址： National Institutes of Health Office of Technology Transfer, 6011 Executive Blvd., Suite 325, Rockville, MD 20852-3804 US
- 代理机构： ALTMAN, Daniel, E.
- 优先权： US60/753,437 20051222; US60/763,786 20060130; US60/779,855 20060307
- 主分类号： C07K16/00
- IPC分类号： C07K16/00
摘要：
The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要（中）：
本发明涉及结合或中和正痘病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体保留B5或A33结合能力的片段，完全人抗体保留B5或A33结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。