发明申请
WO2007071311A1 2 -PHENYLETHYLAMINO DERIVATIVES AS CALCIUM AND/OR SODIUM CHANNEL MODULATORS
审中-公开
基本信息:
- 专利标题： 2 -PHENYLETHYLAMINO DERIVATIVES AS CALCIUM AND/OR SODIUM CHANNEL MODULATORS
- 专利标题（中）：作为钙和/或钠通道调节剂的2-苯乙烯胺衍生物
- 申请号：PCT/EP2006/011443 申请日：2006-11-29
- 公开(公告)号：WO2007071311A1 公开(公告)日：2007-06-28
- 发明人： THALER, Florian , NAPOLETANO, Mauro , SABIDO-DAVID, Cibele , MORIGGI, Ermanno , CACCIA, Carla , FARAVELLI, Laura , RESTIVO, Alessandra , SALVATI, Patricia
- 申请人： NEWRON PHARMACEUTICALS S.P.A. , THALER, Florian , NAPOLETANO, Mauro , SABIDO-DAVID, Cibele , MORIGGI, Ermanno , CACCIA, Carla , FARAVELLI, Laura , RESTIVO, Alessandra , SALVATI, Patricia
- 申请人地址： Via Ariosto, 21, I-20091 Bresso (MI) IT
- 专利权人： NEWRON PHARMACEUTICALS S.P.A.,THALER, Florian,NAPOLETANO, Mauro,SABIDO-DAVID, Cibele,MORIGGI, Ermanno,CACCIA, Carla,FARAVELLI, Laura,RESTIVO, Alessandra,SALVATI, Patricia
- 当前专利权人： NEWRON PHARMACEUTICALS S.P.A.,THALER, Florian,NAPOLETANO, Mauro,SABIDO-DAVID, Cibele,MORIGGI, Ermanno,CACCIA, Carla,FARAVELLI, Laura,RESTIVO, Alessandra,SALVATI, Patricia
- 当前专利权人地址： Via Ariosto, 21, I-20091 Bresso (MI) IT
- 代理机构： SGARBI, Renato et al.
- 优先权： EP05028147.6 20051222
- 主分类号： C07D237/06
- IPC分类号： C07D237/06 ; C07D295/18 ; C07D307/52 ; C07D295/08 ; C07D309/06 ; C07D307/14 ; C07D261/08 ; C07D213/30 ; C07D213/38 ; A61K31/33 ; A61K31/165 ; A61P25/00 ; A61P9/00 ; A61P13/00 ; A61P27/00
摘要：
2-Phenylethylamino substituted carboxamide derivatives of formula (I); wherein J, W, R, R 0 R 1 , R 2 , R 3 , and R 4 have the meanings as defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urology, and gastrointestinal diseases where the above mechanisms have been described as playing a pathological role, are described.
摘要（中）：
式（I）的2-苯基乙基氨基取代的甲酰胺衍生物; 其中J，W，R，R 0，R 1，R 2，R 3和R 2 > 4 具有本说明书及其药学上可接受的盐中所定义的含义，含有它们作为活性成分的药物组合物及其作为钠和/或钙通道调节剂的用途，其可用于预防缓解和治愈多种病变， 描述了上述机制已被描述为发挥病理作用的神经，精神，心血管，炎症，眼科，泌尿科和胃肠道疾病。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D237/00 | 杂环化合物，含1,2-二嗪环或氢化1,2-二嗪环 |
| --------C07D237/02 | .不与其他环稠合 |
| ----------C07D237/06 | ..环原子间或环原子与非环原子间有3个双键 |