发明申请
WO2007070359A2 QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF
审中-公开
基本信息:
- 专利标题： QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF
- 专利标题（中）：基于喹啉酮的化合物展示了丙烯酸羟化酶的抑制活性及其组合物及其用途
- 申请号：PCT/US2006/046785 申请日：2006-12-08
- 公开(公告)号：WO2007070359A2 公开(公告)日：2007-06-21
- 发明人： ALLEN, Jennifer R. , TEGLEY, Christopher M. , BISWAS, Kaustav , BURLI, Roland , MULLER, Kristine M. , FROHN, Michael J. , GOLDEN, Jennifer E. , MERCEDE, Stephanie J. , NEIRA, Susana C. , PETERKIN, Tanya A. N. , HUNGATE, Randall W. , KURZEJA, Robert , YU, Violeta , DAO, Jennifer
- 申请人： AMGEN INC. , ALLEN, Jennifer R. , TEGLEY, Christopher M. , BISWAS, Kaustav , BURLI, Roland , MULLER, Kristine M. , FROHN, Michael J. , GOLDEN, Jennifer E. , MERCEDE, Stephanie J. , NEIRA, Susana C. , PETERKIN, Tanya A. N. , HUNGATE, Randall W. , KURZEJA, Robert , YU, Violeta , DAO, Jennifer
- 申请人地址： One Amgen Center Drive, Thousand Oaks, California 91320-1799 US
- 专利权人： AMGEN INC.,ALLEN, Jennifer R.,TEGLEY, Christopher M.,BISWAS, Kaustav,BURLI, Roland,MULLER, Kristine M.,FROHN, Michael J.,GOLDEN, Jennifer E.,MERCEDE, Stephanie J.,NEIRA, Susana C.,PETERKIN, Tanya A. N.,HUNGATE, Randall W.,KURZEJA, Robert,YU, Violeta,DAO, Jennifer
- 当前专利权人： AMGEN INC.,ALLEN, Jennifer R.,TEGLEY, Christopher M.,BISWAS, Kaustav,BURLI, Roland,MULLER, Kristine M.,FROHN, Michael J.,GOLDEN, Jennifer E.,MERCEDE, Stephanie J.,NEIRA, Susana C.,PETERKIN, Tanya A. N.,HUNGATE, Randall W.,KURZEJA, Robert,YU, Violeta,DAO, Jennifer
- 当前专利权人地址： One Amgen Center Drive, Thousand Oaks, California 91320-1799 US
- 代理机构： GARRETT, Arthur, S.
- 优先权： US60/748,577 20051209; US60/785,358 20060324
摘要：
This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
摘要（中）：
本发明涉及显示脯氨酰羟化酶抑制活性的新型喹诺酮类化合物。 本发明还涉及通过向受试者施用至少一种基于喹诺酮的化合物来增加受试者中HIF水平或活性或治疗与受试者中HIF水平或活性相关的病症的方法。 本发明还涉及用于检测HIF分子中的羟脯氨酸残基的测定法。