基本信息:
- 专利标题： COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF NAV1.8 GENE
- 专利标题（中）：用于抑制NAV1.8基因表达的组合物和方法
- 申请号：PCT/US2006/043252 申请日：2006-11-03
- 公开(公告)号：WO2007056326A2 公开(公告)日：2007-05-18
- 发明人： SAH, Dinah, Wen-Yee , FRANK-KAMENETSKY, Maria , GEICK, Anke , HADWIGER, Philipp , ROEHL, Ingo , TAN, Pamela , VORNLOCHER, Hans-Peter
- 申请人： ALNYLAM PHARMACEUTICALS, INC. , SAH, Dinah, Wen-Yee , FRANK-KAMENETSKY, Maria , GEICK, Anke , HADWIGER, Philipp , ROEHL, Ingo , TAN, Pamela , VORNLOCHER, Hans-Peter
- 申请人地址： 300 Third Street, Cambridge, Massachusetts 02142 US
- 专利权人： ALNYLAM PHARMACEUTICALS, INC.,SAH, Dinah, Wen-Yee,FRANK-KAMENETSKY, Maria,GEICK, Anke,HADWIGER, Philipp,ROEHL, Ingo,TAN, Pamela,VORNLOCHER, Hans-Peter
- 当前专利权人： ALNYLAM PHARMACEUTICALS, INC.,SAH, Dinah, Wen-Yee,FRANK-KAMENETSKY, Maria,GEICK, Anke,HADWIGER, Philipp,ROEHL, Ingo,TAN, Pamela,VORNLOCHER, Hans-Peter
- 当前专利权人地址： 300 Third Street, Cambridge, Massachusetts 02142 US
- 代理机构： MYERS, Louis et al.
- 优先权： US60/733,816 20051104; US60/741,586 20051202; US60/763,202 20060126; US60/795,443 20060427; US60/849,364 20061004
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07J17/00 ; C07H21/02 ; C12N5/10 ; C12N5/08 ; C07F9/6533
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell
摘要（中）：
本发明涉及用于抑制Nav1.8基因（Nav1.8基因）表达的双链核糖核酸（dsRNA），其包含长度小于25个核苷酸的核苷酸序列的反义链，其基本上 与Nav1.8基因的至少一部分互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由使用该药物组合物的Nav1.8基因表达引起的疾病的方法; 以及抑制细胞中Nav1.8基因表达的方法
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K48/00 | 含有插入到活体细胞中的遗传物质以治疗遗传病的医药配制品；基因治疗 |