基本信息:
- 专利标题： ACRYLAMIDE DERIVATIVES AS ANTIBIOTIC AGENTS
- 专利标题（中）：丙烯酰胺衍生物作为抗生素
- 申请号：PCT/US2005019805 申请日：2005-06-06
- 公开(公告)号：WO2007053131A3 公开(公告)日：2007-08-02
- 发明人： SARGENT BRUCE JEREMY , PAULS HENRY , BERMAN JUDD M , RAMNAUTH JAILALL , SAMPSON PETER , TORO ANDRAS , MARTIN FERNANDO J L , SURMAN MATTHEW DAVID , DECORNEZ HELENE YVONNE , MANNING DAVID DOUGLAS
- 申请人： AFFINIUM PHARM INC , SARGENT BRUCE JEREMY , PAULS HENRY , BERMAN JUDD M , RAMNAUTH JAILALL , SAMPSON PETER , TORO ANDRAS , MARTIN FERNANDO J L , SURMAN MATTHEW DAVID , DECORNEZ HELENE YVONNE , MANNING DAVID DOUGLAS
- 专利权人： AFFINIUM PHARM INC,SARGENT BRUCE JEREMY,PAULS HENRY,BERMAN JUDD M,RAMNAUTH JAILALL,SAMPSON PETER,TORO ANDRAS,MARTIN FERNANDO J L,SURMAN MATTHEW DAVID,DECORNEZ HELENE YVONNE,MANNING DAVID DOUGLAS
- 当前专利权人： AFFINIUM PHARM INC,SARGENT BRUCE JEREMY,PAULS HENRY,BERMAN JUDD M,RAMNAUTH JAILALL,SAMPSON PETER,TORO ANDRAS,MARTIN FERNANDO J L,SURMAN MATTHEW DAVID,DECORNEZ HELENE YVONNE,MANNING DAVID DOUGLAS
- 优先权： US57694504 2004-06-04
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/4375 ; A61K31/443 ; A61K31/4436 ; A61K31/4439 ; A61K31/5365 ; A61K31/551 ; A61P31/04 ; C07D405/12 ; C07D409/12 ; C07D471/04 ; C07D498/04
摘要：
The present invention is directed to antibacterial compounds formula (I), wherein, independently for each occurrence, A is a monocyclic ring of 4-7 atoms containing 0-2 heteroatoms, a bicyclic ring of 8-12 atoms containing 0-4 heteroatoms or a tricyclic ring of 8-12 atoms containing 0-6 heteroatoms wherein the rings are independently aliphatic, aromatic, heteroaryl or heterocyclic in nature, the heteroatoms are selected from N, S or O and the rings are optionally substituted with one or more groups selected from CM alkyl, OR", CN, OCF 3 , F, Cl, Br, I; wherein R" is H, alkyl, aralkyl, or heteroaralkyl; R is formula (II), (III), (IV), (V), (VI), (VII) wherein, independently for each occurrence, R 1 is H, alkyl, or aryl, or R 1 and R 2 taken together form a fused ring; R 2 is H, alkyl, or aryl, or R 2 and R 1 taken together form a fused ring, or R 2 and R 3 taken together form a spirocyclic ring; R 3 is H, alkyl, or aryl, or R 3 and R 2 taken together form a spirocyclic ring; R 4 is H, alkyl, aryl, hydroxy substituted alkyl, or -C(O)ONa; R 5 is H, alkyl, or aryl; R 6 is H, alkyl, or aryl; and L 1 is O or H 2 .
摘要（中）：
本发明涉及抗菌化合物式（I），其中独立地，对于每次出现，A是含有0-2个杂原子的4-7个原子的单环，含有0-4个杂原子的8-12个原子的双环或 含有0-6个杂原子的8-12个原子的三环，其中环在本质上独立地是脂族，芳族，杂芳基或杂环，杂原子选自N，S或O，并且该环任选地被一个或多个被选择的基团取代 来自CM烷基，OR“，CN，OCF 3，F，Cl，Br，I;其中R”是H，烷基，芳烷基或杂芳烷基; R是式（II），（III），（IV），（V），（VI），（VII）其中R 1独立地为H，烷基或芳基， 或R 1和R 2一起形成稠环; R 2是H，烷基或芳基，或R 2和R 1一起形成稠环，或R 2 R 3和R 3一起形成螺环; R 3是H，烷基或芳基，或R 3和R 2一起形成螺环; R 4是H，烷基，芳基，羟基取代的烷基或-C（O）ONa; R 5是H，烷基或芳基; R 6是H，烷基或芳基; 且L 1是O或H 2 H 2。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D401/00 | 杂环化合物，含有两个或更多个杂环，以氮原子作为仅有的杂环原子，至少有1个环是仅含有1个氮原子的六元环 |
| --------C07D401/02 | .含有两个杂环 |
| ----------C07D401/12 | ..被含有杂原子的链作为键链连接的 |