基本信息:
- 专利标题： METHOD TO TREAT FLAVIVIRUS INFECTION WITH SIRNA
- 专利标题（中）：用SIRNA治疗感染FLAVIVIRUS的方法
- 申请号：PCT/US2006/038980 申请日：2006-10-05
- 公开(公告)号：WO2007044468A2 公开(公告)日：2007-04-19
- 发明人： SWAMY, Manjunath, N. , SHANKAR, Premlata , KUMAR, Priti , LEE, Sang-Kyung
- 申请人： THE CBR INSTITUTE FOR BIOMEDICAL RESEARCH, INC. , SWAMY, Manjunath, N. , SHANKAR, Premlata , KUMAR, Priti , LEE, Sang-Kyung
- 申请人地址： 800 Huntington Avenue, Boston, MA 02115 US
- 专利权人： THE CBR INSTITUTE FOR BIOMEDICAL RESEARCH, INC.,SWAMY, Manjunath, N.,SHANKAR, Premlata,KUMAR, Priti,LEE, Sang-Kyung
- 当前专利权人： THE CBR INSTITUTE FOR BIOMEDICAL RESEARCH, INC.,SWAMY, Manjunath, N.,SHANKAR, Premlata,KUMAR, Priti,LEE, Sang-Kyung
- 当前专利权人地址： 800 Huntington Avenue, Boston, MA 02115 US
- 代理机构： RESNICK, David, S. et al.
- 优先权： US60/723,686 20051005
- 主分类号： A61K48/00
- IPC分类号： A61K48/00
摘要：
The present invention is directed to methods of treating flavivirus mediated diseases using siRNAs. The invention is based upon our findings in a mouse model that siRNAs directed against sequences conserved among multiple flaviviruses prevents and treats flavivirus infections. Accordingly, the present invention provides an isolated siRNA comprising a sense RNA and an antisense RNA strand or a single strand. The sense and the antisense RNA strands, or the single RNA strand, form an RNA duplex, and wherein the RNA strand comprises a nucleotide sequence identical to a target sequence of about 15 to about 30 contiguous nucleotides in flavivirus mRNA or mutant or variant thereof.
摘要（中）：
本发明涉及使用siRNA治疗黄病毒介导的疾病的方法。 本发明基于我们在小鼠模型中的发现，其针对多种黄病毒中保守的序列的siRNA预防和治疗黄病毒感染。 因此，本发明提供了包含有义RNA和反义RNA链或单链的分离的siRNA。 有义和反义RNA链或单RNA链形成RNA双链体，其中RNA链包含与黄病毒mRNA或突变体或变体中约15至约30个连续核苷酸的靶序列相同的核苷酸序列。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K48/00 | 含有插入到活体细胞中的遗传物质以治疗遗传病的医药配制品；基因治疗 |