基本信息:
- 专利标题： METHOD FOR PREPARING IMMUNOGLOBULIN LIBRARIES
- 申请号：PCT/EP2006/066355 申请日：2006-09-14
- 公开(公告)号：WO2007031550A3 公开(公告)日：2007-03-22
- 发明人： THROSBY, Mark , DE KRUIF, Cornelis Adriaan , BAKKER, Adrianus Quirinus
- 申请人： CRUCELL HOLLAND B.V. , THROSBY, Mark , DE KRUIF, Cornelis Adriaan , BAKKER, Adrianus Quirinus
- 申请人地址： Archimedesweg 4, NL-2333 CN Leiden NL
- 专利权人： CRUCELL HOLLAND B.V.,THROSBY, Mark,DE KRUIF, Cornelis Adriaan,BAKKER, Adrianus Quirinus
- 当前专利权人： CRUCELL HOLLAND B.V.,THROSBY, Mark,DE KRUIF, Cornelis Adriaan,BAKKER, Adrianus Quirinus
- 当前专利权人地址： Archimedesweg 4, NL-2333 CN Leiden NL
- 代理机构： BIERMANN, Jan et al.
- 优先权： US60/717,685 20050915; EP05108488.7 20050915; EP05111782.8 20051207; EP05111783.6 20051207
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; C40B40/02 ; C07K16/10 ; A61K39/42
摘要：
The invention relates to methods of construction of human immunoglobulin libraries, by isolating B memory cells (IgM memory, class-switched or plasma blast cells) . The libraries are generated on the surface of replicable genetic packages, such as phages. It also relates to methods of screening said libraries and the immunoglobulins identified in said screenings. Additionally, the invention relates to human binding molecules that bind to H5N1 virus, in particular antibodies and immunoconjugates. Pharmaceutical compositions comprising said binding molecules are also disclosed.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |