发明申请
WO2007002313A2 PHENYLGLYCINAMIDE AND PYRIDYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS
审中-公开
基本信息:
- 专利标题： PHENYLGLYCINAMIDE AND PYRIDYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS
- 专利标题（中）：苯丙胺和吡咯烷酮衍生物作为抗凝剂有用
- 申请号：PCT/US2006/024345 申请日：2006-06-22
- 公开(公告)号：WO2007002313A2 公开(公告)日：2007-01-04
- 发明人： ZHANG, Xiaojun , NIRSCHL, Alexandra A. , ZOU, Yan , PRIESTLEY, Eldon Scott
- 申请人： BRISTOL-MYERS SQUIBB COMPANY , ZHANG, Xiaojun , NIRSCHL, Alexandra A. , ZOU, Yan , PRIESTLEY, Eldon Scott
- 申请人地址： Route 206 And Province Line Road, Princeton, New Jersey 08543-4000 US
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY,ZHANG, Xiaojun,NIRSCHL, Alexandra A.,ZOU, Yan,PRIESTLEY, Eldon Scott
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY,ZHANG, Xiaojun,NIRSCHL, Alexandra A.,ZOU, Yan,PRIESTLEY, Eldon Scott
- 当前专利权人地址： Route 206 And Province Line Road, Princeton, New Jersey 08543-4000 US
- 代理机构： SUN, Jing G. et al.
- 优先权： US60/694,074 20050624; US60/694,076 20050624
摘要：
The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables W, W 1 , Y, Z, R 7 , R 8 , R 9 , and R 11 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
摘要（中）：
本发明提供式（I）或（IV）的新型苯基甘氨酰胺衍生物：或其立体异构体，互变异构体，药学上可接受的盐，溶剂合物或前药，其中变量W，W 1，Y， Z，R 7，R 8，R 9和R 11如本文所定义。 这些化合物是可用作药物的因子VIIa的选择性抑制剂。