基本信息:
- 专利标题： HIGH AFFINITY ANTIBODIES AGAINST HMGB1 AND METHODS OF USE THEREOF
- 专利标题（中）：HMGB1的高亲和力抗体及其使用方法
- 申请号：PCT/US2005037734 申请日：2005-10-21
- 公开(公告)号：WO2007001422A2 公开(公告)日：2007-01-04
- 发明人： WU HERREN , ALLAN CHRISTIAN B , GAO CHANGSHOU , AN LING-LING , KIENER PETER , MAO SU-YAU , COYLE ANTHONY
- 申请人： MEDIMMUNE INC , WU HERREN , ALLAN CHRISTIAN B , GAO CHANGSHOU , AN LING-LING , KIENER PETER , MAO SU-YAU , COYLE ANTHONY
- 专利权人： MEDIMMUNE INC,WU HERREN,ALLAN CHRISTIAN B,GAO CHANGSHOU,AN LING-LING,KIENER PETER,MAO SU-YAU,COYLE ANTHONY
- 当前专利权人： MEDIMMUNE INC,WU HERREN,ALLAN CHRISTIAN B,GAO CHANGSHOU,AN LING-LING,KIENER PETER,MAO SU-YAU,COYLE ANTHONY
- 优先权： US62072604 2004-10-22; US65151205 2005-02-10; US65857205 2005-03-07; US66294405 2005-03-18; US71371205 2005-09-06
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/40
摘要：
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.
摘要（中）：
公开了用于抑制促炎细胞因子从脊椎动物细胞中释放并抑制患者炎性细胞因子级联的组合物和方法。 组合物包含例如特异性结合HMG1的高亲和力抗体及其抗原性片段。 本发明的高亲和力抗体和包含其的药物组合物可用于许多目的，例如作为针对广泛范围的炎性疾病和病症的治疗剂，例如败血症，类风湿性关节炎，腹膜炎，克罗恩病，再灌注损伤，败血症 内毒素性休克，囊性纤维化，心内膜炎，牛皮癣，牛皮癣关节炎，关节炎，过敏性休克，器官缺血，再灌注损伤和同种异体移植排斥。 此外，本发明的高亲和力抗体可用作诊断抗体。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/395 | .抗体；免疫球蛋白；免疫血清，例如抗淋巴细胞血清 |