发明申请
WO2006130613A3 SUBSTITUTED BIARYLHETEROCYCLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES
审中-公开
基本信息:
- 专利标题： SUBSTITUTED BIARYLHETEROCYCLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES
- 专利标题（中）：作为用于治疗癌症和其他疾病的蛋白激酶抑制剂的替代性二异氰尿嘧啶衍生物
- 申请号：PCT/US2006020986 申请日：2006-05-30
- 公开(公告)号：WO2006130613A3 公开(公告)日：2007-02-08
- 发明人： YOUNG YANG , YOUNG PRANEE , MIRANDA MARTIN , PFAHL MICHAELA , CARTER BRUCE , MUTHALIF MUBARACK , PFAHL MAGNUS
- 申请人： PFAHL FAMILY TRUST DATED 9 JUL , YOUNG YANG , YOUNG PRANEE , MIRANDA MARTIN , PFAHL MICHAELA , CARTER BRUCE , MUTHALIF MUBARACK , PFAHL MAGNUS
- 专利权人： PFAHL FAMILY TRUST DATED 9 JUL,YOUNG YANG,YOUNG PRANEE,MIRANDA MARTIN,PFAHL MICHAELA,CARTER BRUCE,MUTHALIF MUBARACK,PFAHL MAGNUS
- 当前专利权人： PFAHL FAMILY TRUST DATED 9 JUL,YOUNG YANG,YOUNG PRANEE,MIRANDA MARTIN,PFAHL MICHAELA,CARTER BRUCE,MUTHALIF MUBARACK,PFAHL MAGNUS
- 优先权： US68606205 2005-05-31
- 主分类号： C07D413/04
- IPC分类号： C07D413/04
摘要：
The present invention is directed to certain patentable substituted benzoxazole derivatives that exhibit protein kinase (PK) inhibition activity or modulating ability. Pharmaceutical compositions comprising these compounds, and methods for preparing and using them, are also described. For example, these heterocyclic compounds are useful in treating disorders related to abnormal PK activity, including diseases and disorders involving aberrant cell proliferation, for example, AML, CML, gastrointestinal stromal cancers, thyroid cancer, other cancers and leukemias, as well as other diseases such as inflammation and atherosclerosis.
摘要（中）：
本发明涉及具有蛋白激酶（PK）抑制活性或调节能力的某些可获得专利的取代苯并恶唑衍生物。 还描述了包含这些化合物的药物组合物，以及制备和使用它们的方法。 例如，这些杂环化合物可用于治疗与异常PK活性相关的疾病，包括涉及异常细胞增殖的疾病和病症，例如AML，CML，胃肠道间质癌，甲状腺癌，其他癌症和白血病，以及其他疾病 如炎症和动脉粥样硬化。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D413/00 | 杂环化合物，含两个或更多个杂环，至少有1个环有氮原子和氧原子作为仅有的杂环原子 |
| --------C07D413/02 | .含两个杂环 |
| ----------C07D413/04 | ..被环原子—环原子的键直接连接的 |