发明申请
WO2006104406A1 TRICYCLIC 1,2,4-TRIAZINE OXIDES AND COMPOSITIONS THEREFROM FOR THERAPEUTIC USE IN CANCER TREATMENTS
审中-公开
基本信息:
- 专利标题： TRICYCLIC 1,2,4-TRIAZINE OXIDES AND COMPOSITIONS THEREFROM FOR THERAPEUTIC USE IN CANCER TREATMENTS
- 专利标题（中）：三联1,2,4-三唑氧化物及其治疗用于治疗癌症的组合物
- 申请号：PCT/NZ2006/000064 申请日：2006-03-31
- 公开(公告)号：WO2006104406A1 公开(公告)日：2006-10-05
- 发明人： HAY, Michael, Patrick , BLASER, Adrian , DENNY, William, Alexander , HICKS, Kevin, Owen , LEE, Ho, Huat , PCHALEK, Karin , PRUIJN, Frederik, Bastiaan , SIIM, Bronwyn, Gae , WILSON, William, Robert , YANG, Shangjin
- 申请人： AUCKLAND UNISERVICES LIMITED , HAY, Michael, Patrick , BLASER, Adrian , DENNY, William, Alexander , HICKS, Kevin, Owen , LEE, Ho, Huat , PCHALEK, Karin , PRUIJN, Frederik, Bastiaan , SIIM, Bronwyn, Gae , WILSON, William, Robert , YANG, Shangjin
- 申请人地址： Level 10, 70 Symonds Street, Auckland, 1001 NZ
- 专利权人： AUCKLAND UNISERVICES LIMITED,HAY, Michael, Patrick,BLASER, Adrian,DENNY, William, Alexander,HICKS, Kevin, Owen,LEE, Ho, Huat,PCHALEK, Karin,PRUIJN, Frederik, Bastiaan,SIIM, Bronwyn, Gae,WILSON, William, Robert,YANG, Shangjin
- 当前专利权人： AUCKLAND UNISERVICES LIMITED,HAY, Michael, Patrick,BLASER, Adrian,DENNY, William, Alexander,HICKS, Kevin, Owen,LEE, Ho, Huat,PCHALEK, Karin,PRUIJN, Frederik, Bastiaan,SIIM, Bronwyn, Gae,WILSON, William, Robert,YANG, Shangjin
- 当前专利权人地址： Level 10, 70 Symonds Street, Auckland, 1001 NZ
- 代理机构： BALDWINS
- 优先权： NZ539152 20050331; NZ542556 20050922
- 主分类号： C07D253/10
- IPC分类号： C07D253/10 ; A61K31/53 ; A61P35/00 ; C07D471/04 ; C07D487/04 ; C07D491/048 ; C07D491/052 ; C07D491/056
摘要：
The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula: (I); and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
摘要（中）：
本发明涉及式（I）的新型三环1,2,4-三嗪-1-氧化物和新型三环1,2,4-三嗪-1,4-二氧化物： 以及相关类似物，其制备方法，以及它们作为用于癌症治疗的缺氧选择性药物和放射增敏剂的用途，单独或与辐射和/或其它抗癌药物组合。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D253/00 | 杂环化合物，含六元环、有3个氮原子作为仅有的杂环原子，C07D251/00组不包含的 |
| --------C07D253/02 | .不和其他环稠合 |
| ----------C07D253/10 | ..稠合的1,2,4-三嗪；氢化的稠合1,2,4-三嗪 |