基本信息:
- 专利标题: SYNTHETIC PROCESS
- 专利标题(中):合成方法
- 申请号:PCT/US2005/047630 申请日:2005-12-21
- 公开(公告)号:WO2006069395A2 公开(公告)日:2006-06-29
- 发明人: CHEN, Ping , NORRIS, Derek, J. , GAVAI, Ashvinikumar, V.
- 申请人: BRISTOL-MYERS SQUIBB COMPANY , CHEN, Ping , NORRIS, Derek, J. , GAVAI, Ashvinikumar, V.
- 申请人地址: Route 206 and Province Line Road, Princeton, New Jersey 08543-4000 US
- 专利权人: BRISTOL-MYERS SQUIBB COMPANY,CHEN, Ping,NORRIS, Derek, J.,GAVAI, Ashvinikumar, V.
- 当前专利权人: BRISTOL-MYERS SQUIBB COMPANY,CHEN, Ping,NORRIS, Derek, J.,GAVAI, Ashvinikumar, V.
- 当前专利权人地址: Route 206 and Province Line Road, Princeton, New Jersey 08543-4000 US
- 代理机构: KORSEN, Elliott et al.
- 优先权: US60/638,335 20041222
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61K31/53 ; A61P35/00 ; C07D239/94 ; C07D401/06
摘要:
The present invention provides a process for preparing compounds of formula (IV), or a pharmaceutically acceptable salt thereof. The compounds prepared by the process of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
摘要(中):
本发明提供制备式(Ⅳ)化合物或其可药用盐的方法。 通过本发明的方法制备的化合物抑制生长因子受体如HER1,HER2和HER4的酪氨酸激酶活性,从而使其可用作治疗癌症和其它疾病的抗增殖剂。
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D487/00 | 在稠环系中含有氮原子作为仅有的杂环原子的杂环化合物,不包含在C07D451/00至C07D477/00组中 |
--------C07D487/02 | .在稠合系中含有两个杂环 |
----------C07D487/04 | ..邻位稠合系 |