发明申请
WO2006048720A1 AN EFFICIENT METHOD FOR PREPARATION OF (S)-3-[(1-DIMETHYL AMINO)ETHYL]-PHENYL-N-ETHYL-N-METHYL-CARBAMATE
审中-公开
基本信息:
- 专利标题： AN EFFICIENT METHOD FOR PREPARATION OF (S)-3-[(1-DIMETHYL AMINO)ETHYL]-PHENYL-N-ETHYL-N-METHYL-CARBAMATE
- 专利标题（中）：制备（S）-3 - [（1-二甲基氨基）乙基] - 苯基-N-乙基-N-甲基 - 碳酸酯的有效方法
- 申请号：PCT/IB2005/003237 申请日：2005-10-29
- 公开(公告)号：WO2006048720A1 公开(公告)日：2006-05-11
- 发明人： GHARPURE, Milind, Moreshwar , BHAWAL, Baburao, Manikrao , SHAH, Viral, Bipinbhai , ZOPE, Umesh, Rewaji , MEHTA, Satish, Ramanlal
- 申请人： EMCURE PHARMACEUTICALS LIMITED , GHARPURE, Milind, Moreshwar , BHAWAL, Baburao, Manikrao , SHAH, Viral, Bipinbhai , ZOPE, Umesh, Rewaji , MEHTA, Satish, Ramanlal
- 申请人地址： EMCURE HOUSE, T-184, MIDC, Bhosari, Pune, Maharashtra 411 018 IN
- 专利权人： EMCURE PHARMACEUTICALS LIMITED,GHARPURE, Milind, Moreshwar,BHAWAL, Baburao, Manikrao,SHAH, Viral, Bipinbhai,ZOPE, Umesh, Rewaji,MEHTA, Satish, Ramanlal
- 当前专利权人： EMCURE PHARMACEUTICALS LIMITED,GHARPURE, Milind, Moreshwar,BHAWAL, Baburao, Manikrao,SHAH, Viral, Bipinbhai,ZOPE, Umesh, Rewaji,MEHTA, Satish, Ramanlal
- 当前专利权人地址： EMCURE HOUSE, T-184, MIDC, Bhosari, Pune, Maharashtra 411 018 IN
- 代理机构： HARIHARAN, Rajeshwari et al.
- 优先权： IN1207/MUM/2004 20041108
- 主分类号： C07C269/04
- IPC分类号： C07C269/04 ; C07C269/00 ; C07C271/44
摘要：
The present invention relates to a method for preparation of substituted phenyl carbamate and pharmaceutically acceptable salts thereof, which are of current pharmaceutical interest. The substituted phenyl carbamate and pharmaceutically acceptable salts thereof are useful to raise cholinergic activity in the central nervous system and useful in treatment of diseases such as Alzheimer's disease, Down's syndrome, Huntingdon's chorea, Friedrich's ataxia etc. (S)-3-[(1-dimethyl amino)ethyl]- phenyl-N-ethyl-N-methyl-carbamate (I) is the active ingredient of the pharmaceutical composition referred in US 5,602,176. This compound is also used to induce selective inhibition of acetylcholinesterase activity in the brain.
摘要（中）：
本发明涉及一种制备目前具有药用价值的取代苯基氨基甲酸酯及其药学上可接受的盐的方法。 取代的氨基甲酸苯酯和其药学上可接受的盐可用于提高中枢神经系统中的胆碱能活性，并且可用于治疗诸如阿尔茨海默氏病，唐氏综合征，亨廷登舞蹈病，弗里德里希共济失调等疾病。（S）-3 - [（1 - 二甲基氨基）乙基] - 苯基-N-乙基-N-甲基 - 氨基甲酸酯（I）是US 5,602,176中所述的药物组合物的活性成分。 该化合物也用于诱导脑中乙酰胆碱酯酶活性的选择性抑制。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C269/00 | 氨基甲酸的衍生物，即含有如下任何基团的化合物NCOO，NCOHal，NCOO，NCOHal或NCHalHal，氮原子不属于硝基或亚硝基的制备 |
| --------C07C269/04 | .由胺形成氨基甲酸酯基 |