发明申请
WO2006046994A2 KLF6 ALTERNATIVE SPLICE FORMS AND A GERMLINE KLF6 DNA POLYMORPHISM ASSOCIATED WITH INCREASED CANCER RISK
审中-公开
基本信息:
- 专利标题: KLF6 ALTERNATIVE SPLICE FORMS AND A GERMLINE KLF6 DNA POLYMORPHISM ASSOCIATED WITH INCREASED CANCER RISK
- 专利标题(中):KLF6替代性粒细胞型和与增加癌症风险相关的GERMLINE KLF6 DNA多态性
- 申请号:PCT/US2005/027578 申请日:2005-08-01
- 公开(公告)号:WO2006046994A2 公开(公告)日:2006-05-04
- 发明人: MARTIGNETTI, John , NARLA, Goutham , FRIEDMAN, Scott
- 申请人: MOUNT SINAI SCHOOL OF MEDICINE , MARTIGNETTI, John , NARLA, Goutham , FRIEDMAN, Scott
- 申请人地址: One Gustave L. Levy Place, New York, NY 10029 US
- 专利权人: MOUNT SINAI SCHOOL OF MEDICINE,MARTIGNETTI, John,NARLA, Goutham,FRIEDMAN, Scott
- 当前专利权人: MOUNT SINAI SCHOOL OF MEDICINE,MARTIGNETTI, John,NARLA, Goutham,FRIEDMAN, Scott
- 当前专利权人地址: One Gustave L. Levy Place, New York, NY 10029 US
- 代理机构: LUDWIG, S., Peter et al.
- 优先权: US60/592,782 20040730; US60/601,304 20040813
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68
摘要:
Disclosed are methods of identifying and diagnosing certain types of cancers and pre-stages thereof in a patient by identifying alternatively spliced isoforms of wild type KLF6 (KLFwt), in particular anyone of the isoforms selected from the group consisting of: KLF6 splice variant-1 (KLF6SV1), KLF6 splice variant-2 (KLF6SV2), and KLF6 splice variant-3 (KLF6SV3). Also disclosed are methods diagnosising cancer using the polypeptides and polynucleotides identified herein, as well as methods of treating certain types of cancers by inhibiting polynucleotides and polypeptides identified herein.
摘要(中):
公开了通过鉴定野生型KLF6(KLFwt)的可变剪接的同种型,特别是选自KLF6剪接变体-1的任何同种型,鉴定和诊断患者中某些类型的癌症及其前期的方法 (KLF6SV1),KLF6剪接变体-2(KLF6SV2)和KLF6剪接变体-3(KLF6SV3)。 还公开了使用本文鉴定的多肽和多核苷酸诊断癌症的方法,以及通过抑制本文鉴定的多核苷酸和多肽来治疗某些类型的癌症的方法。