发明申请
WO2006040569A1 THIOPHENE AMIDE COMPOUNDS FOR USE IN THE TREATMENT OR PROPHYLAXIS OF CANCERS
审中-公开
基本信息:
- 专利标题： THIOPHENE AMIDE COMPOUNDS FOR USE IN THE TREATMENT OR PROPHYLAXIS OF CANCERS
- 专利标题（中）：用于治疗或预防癌症的噻吩类化合物
- 申请号：PCT/GB2005/003957 申请日：2005-10-14
- 公开(公告)号：WO2006040569A1 公开(公告)日：2006-04-20
- 发明人： GILL, Adrian, Liam , LYONS, John, Francis , THOMPSON, Neil, Thomas
- 申请人： ASTEX THERAPEUTICS LIMITED , GILL, Adrian, Liam , LYONS, John, Francis , THOMPSON, Neil, Thomas
- 申请人地址： 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA GB
- 专利权人： ASTEX THERAPEUTICS LIMITED,GILL, Adrian, Liam,LYONS, John, Francis,THOMPSON, Neil, Thomas
- 当前专利权人： ASTEX THERAPEUTICS LIMITED,GILL, Adrian, Liam,LYONS, John, Francis,THOMPSON, Neil, Thomas
- 当前专利权人地址： 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA GB
- 代理机构： HUTCHINS, Michael, R. et al.
- 优先权： US60/618,780 20041014
- 主分类号： A61K31/5386
- IPC分类号： A61K31/5386 ; A61K31/4155 ; A61K31/5377 ; A61K31/496 ; A61K31/4439 ; A61P35/00
摘要：
The invention provides the use of a compound for the manufacture of a medicament for the prophylaxis or treatment of a cancer or a para-neoplastic effect associated with a cancer, the para-neoplastic effect being other than cachexia, and the compound being a compound of the formula (I), or a salt, solvate or N-oxide thereof, wherein: R 1 and R 2 are the same or different and each is selected from hydrogen, C 1-4 hydrocarbyl, halogen and cyano; X is selected from C=O, C=S, C(=O)NH, C(=S)NH, C(=O)O, C(=O)S, C(=S)O and C(=S)S; R 3 is an aryl or heteroaryl group of 5 to 12 ring members optionally substituted by one or more substituent groups R 7 wherein R 7 is as defined in the claims; R 4 is a group YR 5 or a group R 6 ; Y is NH, O or S; R 5 is selected from (a) optionally substituted carbocyclic and heterocyclic groups having from 3 to 12 ring members; and (b) optionally substituted C 1-8 hydrocarbyl 20 groups; and R 6 is an optionally substituted heterocyclic group having from 4 to 12 ring members and containing at least one ring nitrogen atom through which R 6 is linked to the adjacent carbonyl group.
摘要（中）：
本发明提供化合物在制备用于预防或治疗与癌症相关的癌症或副肿瘤作用的药物中的用途，所述副肿瘤作用不是恶病质，所述化合物是化合物 式（I）或其盐，溶剂合物或N-氧化物，其中：R
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/535 | ...有至少1个氮原子和1个氧原子作为杂环原子的六元环的，例如1，2口恶嗪类 |
| --------------A61K31/5375 | ....1,4口恶嗪类，例如，吗啉 |
| ----------------A61K31/5386 | .....螺环稠合或形成桥环部分的 |