发明申请
WO2006023778A3 SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF
审中-公开
基本信息:
- 专利标题： SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF
- 申请号：PCT/US2005/029634 申请日：2005-08-22
- 公开(公告)号：WO2006023778A3 公开(公告)日：2006-03-02
- 发明人： WANG, Shaomeng , WANG, Guoping , TANG, Guozhi , WANG, Renxiao , NIKOLOVSKA-COLESKA, Zaneta , WANG, Dajon , XU, Liang
- 申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WANG, Shaomeng , WANG, Guoping , TANG, Guozhi , WANG, Renxiao , NIKOLOVSKA-COLESKA, Zaneta , WANG, Dajon , XU, Liang
- 申请人地址： 3003 South State Street, Ann Arbor, MI 48109 US
- 专利权人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN,WANG, Shaomeng,WANG, Guoping,TANG, Guozhi,WANG, Renxiao,NIKOLOVSKA-COLESKA, Zaneta,WANG, Dajon,XU, Liang
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN,WANG, Shaomeng,WANG, Guoping,TANG, Guozhi,WANG, Renxiao,NIKOLOVSKA-COLESKA, Zaneta,WANG, Dajon,XU, Liang
- 当前专利权人地址： 3003 South State Street, Ann Arbor, MI 48109 US
- 代理机构： GOETZ, Robert, A. et al.
- 优先权： US60/603,411 20040820; USnone 20050822
- 主分类号： A61K31/075
- IPC分类号： A61K31/075 ; A61K31/47 ; A61K31/495 ; A61K31/5375 ; C07C43/02 ; C07D217/00 ; C07D413/02
摘要：
The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/075 | .醚类或醛缩醇类 |