基本信息:
- 专利标题: GLYCOPEPTIDE DIMERS AND USES THEREOF
- 专利标题(中):谷氨酸二聚体及其用途
- 申请号:PCT/US2005024273 申请日:2005-07-08
- 公开(公告)号:WO2006017180A3 公开(公告)日:2006-07-20
- 发明人: DANISHEFSKY SAMUEL , DUDKIN VADIM , GENG XUDONG , MANDAL MIHIRIBARAN , OLSON WILLIAM , ORLOVA MARIANNA
- 申请人: PROGENICS PHARM INC , SLOAN KETTERING INST CANCER , DANISHEFSKY SAMUEL , DUDKIN VADIM , GENG XUDONG , MANDAL MIHIRIBARAN , OLSON WILLIAM , ORLOVA MARIANNA
- 专利权人: PROGENICS PHARM INC,SLOAN KETTERING INST CANCER,DANISHEFSKY SAMUEL,DUDKIN VADIM,GENG XUDONG,MANDAL MIHIRIBARAN,OLSON WILLIAM,ORLOVA MARIANNA
- 当前专利权人: PROGENICS PHARM INC,SLOAN KETTERING INST CANCER,DANISHEFSKY SAMUEL,DUDKIN VADIM,GENG XUDONG,MANDAL MIHIRIBARAN,OLSON WILLIAM,ORLOVA MARIANNA
- 优先权: US58685904 2004-07-09
- 主分类号: A61K38/16
- IPC分类号: A61K38/16
摘要:
This invention provides compounds represented by the formula: (A-X---) n wherein each A- is independently a carbohydrate represented by the general structure: wherein each of B, C, D, E, F, G, H, I, and J independently represents a sugar moiety, a sugar moiety having a protecting group attached thereto, a hydrogen, or an oxygen protecting group, provided that no more than two of B, C, D, and E is simultaneously a sugar moiety or a sugar moiety having a protecting group attached thereto and that no more than one of F, G, H, and I is simultaneously a sugar moiety or a sugar moiety having a protecting group attached thereto and wherein represents a covalent bond between the carbohydrate and the peptide; wherein each R 1 independently represents a hydrogen or an oxygen protecting group; wherein each R 2A and each R 2B is independently a hydrogen or a nitrogen protecting group; wherein X is a peptide; wherein --- represents a disulfide bond; and wherein n represents an integer = 2.
摘要(中):
本发明提供由下式表示的化合物:其中每个A-独立地是由通式结构表示的碳水化合物:其中B,C,D,E,F, G,H,I和J独立地表示糖部分,具有与其连接的保护基的糖部分,氢或氧保护基,条件是B,C,D和E中不超过两个同时 糖部分或具有与其连接的保护基的糖部分,并且F,G,H和I中不超过一个同时是糖部分或具有与其连接的保护基的糖部分,并且其中表示 碳水化合物和肽; 其中每个R 1独立地表示氢或氧保护基; 其中每个R 2A和每个R 2B独立地是氢或氮保护基; 其中X是肽; 其中---表示二硫键; 并且其中n表示整数= 2。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K38/00 | 含肽的医药配制品 |
--------A61K38/16 | .含有20个以上氨基酸的肽;胃泌激素;生长素抑制素;促黑激素;其衍生物 |