基本信息:
- 专利标题: BINDING MOLECULES CAPABLE OF NEUTRALIZING RABIES VIRUS AND USES THEREOF
- 专利标题(中):能够使RABIES病毒中和的结合分子及其用途
- 申请号:PCT/EP2005052410 申请日:2005-05-26
- 公开(公告)号:WO2005118644A3 公开(公告)日:2006-03-09
- 发明人: BAKKER ALEXANDER BERTHOLD HEND , MARISSEN WILLEM EGBERT , KRAMER ROBERT ARJEN , DE KRUIF CORNELIS ADRIAAN
- 申请人: CRUCELL HOLLAND BV , BAKKER ALEXANDER BERTHOLD HEND , MARISSEN WILLEM EGBERT , KRAMER ROBERT ARJEN , DE KRUIF CORNELIS ADRIAAN
- 专利权人: CRUCELL HOLLAND BV,BAKKER ALEXANDER BERTHOLD HEND,MARISSEN WILLEM EGBERT,KRAMER ROBERT ARJEN,DE KRUIF CORNELIS ADRIAAN
- 当前专利权人: CRUCELL HOLLAND BV,BAKKER ALEXANDER BERTHOLD HEND,MARISSEN WILLEM EGBERT,KRAMER ROBERT ARJEN,DE KRUIF CORNELIS ADRIAAN
- 优先权: EP2005050953 2005-03-03; EP2005050310 2005-01-25; EP2004052772 2004-11-03; EP2004052286 2004-09-23; EP2004051661 2004-07-29; US57502304 2004-05-27; EP2004050943 2004-05-27
- 主分类号: C07K16/10
- IPC分类号: C07K16/10 ; A61K39/395 ; A61P31/14 ; C12N5/10 ; C12N15/13 ; C12N15/63 ; G01N33/569
摘要:
The present invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. Preferably, they can be used in the postexposure prophylaxis of rabies.
摘要(中):
本发明提供了特异性结合狂犬病毒并能够中和病毒的结合分子。 本发明还提供了编码结合分子的核酸分子,包含结合分子的组合物以及鉴定或产生结合分子的方法。 结合分子可用于诊断,预防和/或治疗由狂犬病病毒引起的病症。 优选地,它们可以用于狂犬病的暴露后预防。