基本信息:
- 专利标题： AMINOPYRIDINE DERIVATIVES AS SELECTIVE DOPAMINE D3 AGONISTS
- 专利标题（中）：氨基吡啶衍生物作为选择性多巴胺D3激动剂
- 申请号：PCT/IB2005/001554 申请日：2005-05-17
- 公开(公告)号：WO2005115985A1 公开(公告)日：2005-12-08
- 发明人： ALLERTON, Charlotte, Moira, Norfor , COOK, Andrew, Simon , HEPWORTH, David , MILLER, Duncan, Charles
- 申请人： PFIZER LIMITED , PFIZER INC. , ALLERTON, Charlotte, Moira, Norfor , COOK, Andrew, Simon , HEPWORTH, David , MILLER, Duncan, Charles
- 申请人地址： Ramsgate Road, Sandwich, Kent CT13 9NJ GB
- 专利权人： PFIZER LIMITED,PFIZER INC.,ALLERTON, Charlotte, Moira, Norfor,COOK, Andrew, Simon,HEPWORTH, David,MILLER, Duncan, Charles
- 当前专利权人： PFIZER LIMITED,PFIZER INC.,ALLERTON, Charlotte, Moira, Norfor,COOK, Andrew, Simon,HEPWORTH, David,MILLER, Duncan, Charles
- 当前专利权人地址： Ramsgate Road, Sandwich, Kent CT13 9NJ GB
- 代理机构： WOOD, David, J.
- 优先权： GB0411891.5 200405027; GB0412463.2 20040603
- 主分类号： C07D213/73
- IPC分类号： C07D213/73
摘要：
The present invention provides for compounds of formula (I) which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.
摘要（中）：
本发明提供了作为一类多巴胺激动剂的式（I）化合物，更具体地，一类在D3上对D2有选择性的一类激动剂。 这些化合物可用于治疗和/或预防性功能障碍，例如女性性功能障碍（FSD），特别是女性性唤醒障碍（FSAD），性欲低下症（HSDD;对性不感兴趣），女性高潮 无效（FOD;无法达到性高潮）; 男性性功能障碍，特别是男性勃起功能障碍（MED）。 本文所提及的男性性功能障碍意在包括射精性疾病，例如早泄，无汗（无法达到性高潮）或期望障碍，如性欲低下症（HSDD;对性不感兴趣）。 这些化合物也可用于治疗神经精神障碍和神经变性疾病。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D213/00 | 杂环化合物，含六元环、不与其他环稠合、有1个氮原子作为仅有的杂环原子、环原子间或环原子与非环原子间有3个或更多个双键 |
| --------C07D213/02 | .环原子间或环原子与非环原子间有3个双键 |
| ----------C07D213/04 | ..在环氮原子与非环原子间没有键或只有氢或碳原子直接连在环氮原子上 |
| ------------C07D213/06 | ...除了环氮原子外，只含氢和碳原子 |
| --------------C07D213/62 | ....氧或硫原子 |
| ----------------C07D213/73 | .....未取代的胺基或亚胺基 |