基本信息:
- 专利标题: MODIFIED ANTIGEN-PRESENTING CELLS
- 专利标题(中):改良的抗原细胞
- 申请号:PCT/US2005/017343 申请日:2005-05-18
- 公开(公告)号:WO2005113589A2 公开(公告)日:2005-12-01
- 发明人: HIRANO, Naoto , BUTLER, Marcus , NADLER, Lee, M.
- 申请人: DANA-FARBER CANCER INSTITUTE , HIRANO, Naoto , BUTLER, Marcus , NADLER, Lee, M.
- 申请人地址: 44 Binney Street, Boston, MA 02115 US
- 专利权人: DANA-FARBER CANCER INSTITUTE,HIRANO, Naoto,BUTLER, Marcus,NADLER, Lee, M.
- 当前专利权人: DANA-FARBER CANCER INSTITUTE,HIRANO, Naoto,BUTLER, Marcus,NADLER, Lee, M.
- 当前专利权人地址: 44 Binney Street, Boston, MA 02115 US
- 代理机构: WILLIAMS, Kathleen, M.
- 优先权: US10/850,294 20040520
- 主分类号: C07K14/47
- IPC分类号: C07K14/47
摘要:
The invention relates to antigen-presenting cells having specificity against a selected antigen and methods for making the cells. The invention also relates to a method of selecting efficient antigen-presenting cells using reporter fusion constructs. The highly efficient antigen-presenting cells of the invention will provide a therapeutic strategy of modulating immune responses for a variety of diseases.
摘要(中):
本发明涉及对所选抗原具有特异性的抗原呈递细胞和用于制备细胞的方法。 本发明还涉及使用报道融合构建体选择有效的抗原呈递细胞的方法。 本发明的高效抗原呈递细胞将提供调节各种疾病的免疫应答的治疗策略。