基本信息:
- 专利标题： ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE
- 申请号：PCT/US2005/010969 申请日：2005-03-31
- 公开(公告)号：WO2005097765A1 公开(公告)日：2005-10-20
- 发明人： LEAHY, James William , LEWIS, Gary Lee , NUSS, John M. , RIDGWAY, Brian Hugh , SANGALANG, Joan C.
- 申请人： EXELIXIS, INC. , LEAHY, James William , LEWIS, Gary Lee , NUSS, John M. , RIDGWAY, Brian Hugh , SANGALANG, Joan C.
- 申请人地址： 170 Harbor Way, P.O. Box 511, South San Francisco, California 94083-0511 US
- 专利权人： EXELIXIS, INC.,LEAHY, James William,LEWIS, Gary Lee,NUSS, John M.,RIDGWAY, Brian Hugh,SANGALANG, Joan C.
- 当前专利权人： EXELIXIS, INC.,LEAHY, James William,LEWIS, Gary Lee,NUSS, John M.,RIDGWAY, Brian Hugh,SANGALANG, Joan C.
- 当前专利权人地址： 170 Harbor Way, P.O. Box 511, South San Francisco, California 94083-0511 US
- 代理机构： ATKINS, Michael, J.
- 优先权： US60/558,800 20040331
- 主分类号： C07D277/20
- IPC分类号： C07D277/20
摘要：
The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R 1 , R 2 , R 3 and R 4 are defined herein. The invention also provides methods of using the compounds for inhibition of kinases, more specifically ALK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions; (Formula I).
摘要（中）：
本发明涉及式I化合物，其中L，X，Y，Z，R 1，R 2，R 3和R 4如本文所定义。 本发明还提供了使用化合物抑制激酶，更具体地说是ALK激酶的方法。 本发明提供用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物如上所述抑制，调节和/或调节与细胞活性变化有关的激酶受体信号转导途径，并且本发明包括含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法 ; （式I）。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D277/00 | 杂环化合物，含有1,3-噻唑或氢化1,3-噻唑环 |
| --------C07D277/02 | .不和其他环稠合 |
| ----------C07D277/20 | ..环原子间或环原子与非环原子间有两个或3个双键 |