发明申请
WO2005097073A8 MACROMOLECULAR DELIVERY SYSTEMS FOR NON-INVASIVE IMAGING, EVALUATION AND TREATMENT OF ARTHRITIS AND OTHER INFLAMMATORY DISEASES
审中-公开
基本信息:
- 专利标题： MACROMOLECULAR DELIVERY SYSTEMS FOR NON-INVASIVE IMAGING, EVALUATION AND TREATMENT OF ARTHRITIS AND OTHER INFLAMMATORY DISEASES
- 专利标题（中）：用于非侵入性成像，评估和治疗ARTHRITIS和其他炎症疾病的大分子递送系统
- 申请号：PCT/US2005010801 申请日：2005-03-30
- 公开(公告)号：WO2005097073A8 公开(公告)日：2005-12-08
- 发明人： WANG DONG , KOPECEK JINDRICH , MILLER SCOTT C , KOPECKOVA PAVLA
- 申请人： UNIV UTAH RES FOUND , WANG DONG , KOPECEK JINDRICH , MILLER SCOTT C , KOPECKOVA PAVLA
- 专利权人： UNIV UTAH RES FOUND,WANG DONG,KOPECEK JINDRICH,MILLER SCOTT C,KOPECKOVA PAVLA
- 当前专利权人： UNIV UTAH RES FOUND,WANG DONG,KOPECEK JINDRICH,MILLER SCOTT C,KOPECKOVA PAVLA
- 优先权： US55804704 2004-03-31
- 主分类号： A61F2/00
- IPC分类号： A61F2/00 ; A61K9/14 ; A61K9/20 ; A61K9/22 ; A61K9/48 ; A61K9/52 ; A61K9/66 ; A61K9/70 ; A61K47/48 ; A61K49/12
摘要：
This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.
摘要（中）：
本发明涉及生物技术，更具体地涉及用于成像，评估和/或治疗类风湿性关节炎和其它炎性疾病的水溶性聚合物递送系统。 使用现代MR成像技术，证明了大鼠在佐剂诱导的关节炎中关节炎关节中大分子的特异性积累。 MR造影剂标记的聚合物的吸收和保留与炎症和局部组织损伤的组织病理特征之间的强相关性证明了本发明的大分子递送系统的实际应用。