基本信息:
- 专利标题： METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS
- 专利标题（中）：用于鉴定抗HIV治疗化合物的方法和组合物
- 申请号：PCT/US2004042991 申请日：2004-12-22
- 公开(公告)号：WO2005064008A9 公开(公告)日：2006-09-28
- 发明人： ARIMILLI MURTY N , BECKER MARK M , BIRKUS GABRIEL , BRYANT CLIFFORD , CHEN JAMES M , CHEN XIAOWU , CIHLAR TOMAS , DASTGAH AZAR , EISENBERG EUGENE J , FARDIS MARIA , HATADA MARCOS , HE GONG-XIN , JIN HAOLUN , KIM CHOUNG U , LEE WILLIAM A , LEE CHRISTOPHER P , LIN KUEI-YING , LIU HONGTAO , MACKMAN RICHARD L , MCDERMOTT MARTIN J , MITCHELL MICHAEL L , NELSON PETER H , PYUN HYUNG-JUNG , ROWE TANISHA D , SPARACINO MARK , SWAMINATHAN SUNDARAMOORTHI , TARIO JAMES D , WANG JIANYING , WILLIAMS MATTHEW A , XU LIANHONG , YANG ZHENG-YU , YU RICHARD H , ZHANG JIANCUN , ZHANG LIJUN
- 申请人： GILEAD SCIENCES INC , ARIMILLI MURTY N , BECKER MARK M , BIRKUS GABRIEL , BRYANT CLIFFORD , CHEN JAMES M , CHEN XIAOWU , CIHLAR TOMAS , DASTGAH AZAR , EISENBERG EUGENE J , FARDIS MARIA , HATADA MARCOS , HE GONG-XIN , JIN HAOLUN , KIM CHOUNG U , LEE WILLIAM A , LEE CHRISTOPHER P , LIN KUEI-YING , LIU HONGTAO , MACKMAN RICHARD L , MCDERMOTT MARTIN J , MITCHELL MICHAEL L , NELSON PETER H , PYUN HYUNG-JUNG , ROWE TANISHA D , SPARACINO MARK , SWAMINATHAN SUNDARAMOORTHI , TARIO JAMES D , WANG JIANYING , WILLIAMS MATTHEW A , XU LIANHONG , YANG ZHENG-YU , YU RICHARD H , ZHANG JIANCUN , ZHANG LIJUN
- 专利权人： GILEAD SCIENCES INC,ARIMILLI MURTY N,BECKER MARK M,BIRKUS GABRIEL,BRYANT CLIFFORD,CHEN JAMES M,CHEN XIAOWU,CIHLAR TOMAS,DASTGAH AZAR,EISENBERG EUGENE J,FARDIS MARIA,HATADA MARCOS,HE GONG-XIN,JIN HAOLUN,KIM CHOUNG U,LEE WILLIAM A,LEE CHRISTOPHER P,LIN KUEI-YING,LIU HONGTAO,MACKMAN RICHARD L,MCDERMOTT MARTIN J,MITCHELL MICHAEL L,NELSON PETER H,PYUN HYUNG-JUNG,ROWE TANISHA D,SPARACINO MARK,SWAMINATHAN SUNDARAMOORTHI,TARIO JAMES D,WANG JIANYING,WILLIAMS MATTHEW A,XU LIANHONG,YANG ZHENG-YU,YU RICHARD H,ZHANG JIANCUN,ZHANG LIJUN
- 当前专利权人： GILEAD SCIENCES INC,ARIMILLI MURTY N,BECKER MARK M,BIRKUS GABRIEL,BRYANT CLIFFORD,CHEN JAMES M,CHEN XIAOWU,CIHLAR TOMAS,DASTGAH AZAR,EISENBERG EUGENE J,FARDIS MARIA,HATADA MARCOS,HE GONG-XIN,JIN HAOLUN,KIM CHOUNG U,LEE WILLIAM A,LEE CHRISTOPHER P,LIN KUEI-YING,LIU HONGTAO,MACKMAN RICHARD L,MCDERMOTT MARTIN J,MITCHELL MICHAEL L,NELSON PETER H,PYUN HYUNG-JUNG,ROWE TANISHA D,SPARACINO MARK,SWAMINATHAN SUNDARAMOORTHI,TARIO JAMES D,WANG JIANYING,WILLIAMS MATTHEW A,XU LIANHONG,YANG ZHENG-YU,YU RICHARD H,ZHANG JIANCUN,ZHANG LIJUN
- 优先权： US74069403 2003-12-22
- 主分类号： C12N9/99
- IPC分类号： C12N9/99 ; C12Q1/44 ; A61K31/4155 ; A61K31/66 ; A61K31/665 ; A61K31/675 ; A61P31/18 ; A61P43/00 ; C07D213/75 ; C07D213/85 ; C07D231/12 ; C07D231/20 ; C07D233/42 ; C07D239/48 ; C07D239/80 ; C07D243/04 ; C07D265/18 ; C07D307/68 ; C07D401/06 ; C07D403/06 ; C07D471/14 ; C07D491/04 ; C07F20060101 ; C07F9/02 ; C07F9/38 ; C07F9/40 ; C07F9/44 ; C07F9/58 ; C07F9/62 ; C07F9/645 ; C07F9/6506 ; C07F9/6509 ; C07F9/6512 ; C07F9/653 ; C07F9/6533 ; C07F9/655 ; C07F9/6558 ; C07F9/6561 ; C07F9/6584 ; C12N9/16 ; C12Q1/18 ; C12Q1/37 ; C12Q1/70 ; G01N33/04 ; G01N33/50
摘要：
Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要（中）：
提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。 可以使用新型GS-7340酯水解酶来筛选这些化合物的文库。 还提供了与GS-7340酯水解酶有关的组合物和方法。