基本信息:
- 专利标题： BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS
- 专利标题（中）：结合域 - 免疫球蛋白融合蛋白
- 申请号：PCT/US0324918 申请日：2003-07-26
- 公开(公告)号：WO2005037989A3 公开(公告)日：2007-05-03
- 发明人： LEDBETTER JEFFREY A , HAYDEN-LEDBETTER MARTHA S , THOMPSON PETER A
- 申请人： TRUBION PHARMACEUTICALS INC , LEDBETTER JEFFREY A , HAYDEN-LEDBETTER MARTHA S , THOMPSON PETER A
- 专利权人： TRUBION PHARMACEUTICALS INC,LEDBETTER JEFFREY A,HAYDEN-LEDBETTER MARTHA S,THOMPSON PETER A
- 当前专利权人： TRUBION PHARMACEUTICALS INC,LEDBETTER JEFFREY A,HAYDEN-LEDBETTER MARTHA S,THOMPSON PETER A
- 优先权： US20765502 2002-07-25
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C12N15/09 ; A61K35/12 ; A61K38/00 ; A61K39/00 ; A61K39/395 ; A61P35/00 ; C07H21/04 ; C07K16/28 ; C07K16/46 ; C12N5/0783 ; C12N5/10 ; C12N15/00 ; C12N15/63
摘要：
The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a wild-type IgG1, IGA or IgE hinge region polypeptide or a mutant IgG1 hinge region polypeptide having either zero, one or two cysteine residues, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as polypeptides that are compromised in their ability to form disulfide-linked multimers. The fusion proteins can be recombinantly produced at high expression levels. Also provided are related compositions and methods, including cell surface forms of the fusion proteins and immunotherapeutic applications of the fusion proteins and of polynucleotides encoding such fusion proteins.
摘要（中）：
本发明涉及新型结合域 - 免疫球蛋白融合蛋白，其特征在于一种同源结构如结合抗原，反向受体等的结合域，野生型IgG1，IGA或IgE铰链区多肽或突变型IgG1铰链区多肽 具有零个，一个或两个半胱氨酸残基，以及免疫球蛋白CH2和CH3结构域，并且其能够具有ADCC和/或CDC，同时主要作为其形成二硫键连接多聚体的能力受损的多肽。 可以以高表达水平重组产生融合蛋白。 还提供了相关的组合物和方法，包括融合蛋白的细胞表面形式和融合蛋白的免疫治疗应用以及编码这种融合蛋白的多核苷酸。