基本信息:
- 专利标题： BISPECIFIC ANTIBODIES FOR INDUCING APOPTOSIS OF TUMOR AND DISEASED CELLS
- 专利标题（中）：诱导肿瘤和疾病细胞凋亡的双重抗体
- 申请号：PCT/US2004/025840 申请日：2004-08-09
- 公开(公告)号：WO2005014618A2 公开(公告)日：2005-02-17
- 发明人： CHANG, Chien-Hsing , GOLDENBERG, David, M. , HANSEN, Hans, J. , HORAK, Eva , HORAK, Ivan
- 申请人： IMMUNOMEDICS, INC. , CHANG, Chien-Hsing , GOLDENBERG, David, M. , HANSEN, Hans, J. , HORAK, Eva , HORAK, Ivan
- 申请人地址： 300 American Road, Morris Plains, NJ 07950 US
- 专利权人： IMMUNOMEDICS, INC.,CHANG, Chien-Hsing,GOLDENBERG, David, M.,HANSEN, Hans, J.,HORAK, Eva,HORAK, Ivan
- 当前专利权人： IMMUNOMEDICS, INC.,CHANG, Chien-Hsing,GOLDENBERG, David, M.,HANSEN, Hans, J.,HORAK, Eva,HORAK, Ivan
- 当前专利权人地址： 300 American Road, Morris Plains, NJ 07950 US
- 代理机构： BOOTH, Paul, M.
- 优先权： US60/493,365 20030808
- 主分类号： C07K
- IPC分类号： C07K
摘要：
The bispecific antibodies of the present invention are in the form of a heteroconjugate that inhibits growth and induces apoptosis of a diseased cell and that does not require the recruitment of effector cells. The heteroconjugate has at least two binding arms wherein each of the binding arms possesses a different specificity and need not have apoptotic activity when not conjugated to each other. Also provided are methods of treating and diagnosing a diseased cell using the bispecfic antibodies of the present invention.
摘要（中）：
本发明的双特异性抗体是异源结合物的形式，其抑制生长并诱导病变细胞的凋亡，并且不需要募集效应细胞。 杂合物具有至少两个结合臂，其中每个结合臂具有不同的特异性，并且当不彼此结合时不需要具有凋亡活性。 还提供了使用本发明的双特异性抗体治疗和诊断患病细胞的方法。