基本信息:
- 专利标题： ANTIGEN-PRESENTING CELL VACCINES AND METHODS OF USE THEREOF
- 专利标题（中）：抗原细胞疫苗及其使用方法
- 申请号：PCT/US2004/023881 申请日：2004-07-23
- 公开(公告)号：WO2005009463A2 公开(公告)日：2005-02-03
- 发明人： DUBENSKY, Thomas, W., Jr. , BROCKSTEDT, Dirk, G. , BAHJAT, Keith , HEARST, John, E. , COOK, David , LUCKETT, William, Stanford
- 申请人： CERUS CORPORATION , DUBENSKY, Thomas, W., Jr. , BROCKSTEDT, Dirk, G. , BAHJAT, Keith , HEARST, John, E. , COOK, David , LUCKETT, William, Stanford
- 申请人地址： 2411 Stanwell Drive, Concord, CA 94520 US
- 专利权人： CERUS CORPORATION,DUBENSKY, Thomas, W., Jr.,BROCKSTEDT, Dirk, G.,BAHJAT, Keith,HEARST, John, E.,COOK, David,LUCKETT, William, Stanford
- 当前专利权人： CERUS CORPORATION,DUBENSKY, Thomas, W., Jr.,BROCKSTEDT, Dirk, G.,BAHJAT, Keith,HEARST, John, E.,COOK, David,LUCKETT, William, Stanford
- 当前专利权人地址： 2411 Stanwell Drive, Concord, CA 94520 US
- 代理机构： HAGER, Alicia, J.
- 优先权： US60/490,089 200307024; US60/511,869 2003010015; US60/511,719 2003010015; US60/511,919 2003010015; US60/532,598 2003012024; US60/541,515 20040202; US10/773,618 20040206; US10/773,792 20040206; US60/556,744 20040326; US10/883,599 20040630
- 主分类号： A61K39/04
- IPC分类号： A61K39/04
摘要：
Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigenpresenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.
摘要（中）：
提供了自由活的微生物，其中已经修饰了核酸，使得微生物被减弱以用于增殖和/或包含减弱微生物修复其核酸的能力的遗传突变。 还提供了使用修饰的微生物来加载，激活和/或成熟抗原呈递细胞的方法。 还提供了包含修饰的微生物和/或抗原呈递细胞的疫苗组合物以及使用疫苗的方法。 可以进一步修饰微生物以包括异源抗原，例如肿瘤抗原或感染性疾病抗原，用作抗癌或感染性疾病的疫苗。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/002 | .原生动物抗原 |
| ----------A61K39/04 | ..分枝杆菌属如结核杆菌 |