基本信息:
- 专利标题： GENETIC VACCINES FOR CANCER THERAPY
- 专利标题（中）：癌症治疗遗传疫苗
- 申请号：PCT/US2004/023775 申请日：2004-07-17
- 公开(公告)号：WO2005006864A1 公开(公告)日：2005-01-27
- 发明人： HERWEIJER, Hans , BATES, Mary, Kay , WOLFF, Jon, A. , BUDKER, Vladimir, G. , HAGSTROM, James, E. , MONAHAN, Sean, D. , SLATTUM, Paul, M. , ROZEMA, David, B.
- 申请人： MIRUS BIO CORPORATION , HERWEIJER, Hans , BATES, Mary, Kay , WOLFF, Jon, A. , BUDKER, Vladimir, G. , HAGSTROM, James, E. , MONAHAN, Sean, D. , SLATTUM, Paul, M. , ROZEMA, David, B.
- 申请人地址： 505 S. Rosa Rd., Madison, WI 53719 US
- 专利权人： MIRUS BIO CORPORATION,HERWEIJER, Hans,BATES, Mary, Kay,WOLFF, Jon, A.,BUDKER, Vladimir, G.,HAGSTROM, James, E.,MONAHAN, Sean, D.,SLATTUM, Paul, M.,ROZEMA, David, B.
- 当前专利权人： MIRUS BIO CORPORATION,HERWEIJER, Hans,BATES, Mary, Kay,WOLFF, Jon, A.,BUDKER, Vladimir, G.,HAGSTROM, James, E.,MONAHAN, Sean, D.,SLATTUM, Paul, M.,ROZEMA, David, B.
- 当前专利权人地址： 505 S. Rosa Rd., Madison, WI 53719 US
- 代理机构： JOHNSON, Mark
- 优先权： US60/488,478 20030718; US10/892,882 20040716
- 主分类号： A01N43/04
- IPC分类号： A01N43/04
摘要：
The present invention relates to methods for delivering a genetic immunogen comprising a polynucleotide capable of expressing an antigen. The polynucleotide is delivered to the host via an intravascular route resulting in delivery to extravascular cells, expression of an encoded antigen and induction of an antigen-specific immune response. The methods may be used to enhance an immune response against a cancer cell related antigen.
摘要（中）：
本发明涉及递送包含能够表达抗原的多核苷酸的遗传免疫原的方法。 多核苷酸通过血管内路径被递送至宿主，导致递送至血管外细胞，编码的抗原的表达和抗原特异性免疫应答的诱导。 该方法可用于增强针对癌细胞相关抗原的免疫应答。