发明申请
WO2004110436A1 FUSED INDOLES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
审中-公开
基本信息:
- 专利标题： FUSED INDOLES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
- 专利标题（中）：作为用于治疗或预防糖尿病的DIPIPTIDYL PEPTIDASE抑制剂的融合吲哚
- 申请号：PCT/US2004/017111 申请日：2004-06-02
- 公开(公告)号：WO2004110436A1 公开(公告)日：2004-12-23
- 发明人： EDMONDSON, Scott, D. , MASTRACCHIO, Anthony , PARMEE, Emma, R.
- 申请人： MERCK & CO., INC. , EDMONDSON, Scott, D. , MASTRACCHIO, Anthony , PARMEE, Emma, R.
- 申请人地址： 126 East Lincoln Avenue, Rahway, NJ 07065-0907 US
- 专利权人： MERCK & CO., INC.,EDMONDSON, Scott, D.,MASTRACCHIO, Anthony,PARMEE, Emma, R.
- 当前专利权人： MERCK & CO., INC.,EDMONDSON, Scott, D.,MASTRACCHIO, Anthony,PARMEE, Emma, R.
- 当前专利权人地址： 126 East Lincoln Avenue, Rahway, NJ 07065-0907 US
- 代理机构： MERCK & CO., INC.
- 优先权： US60/476,883 20030606
- 主分类号： A61K31/403
- IPC分类号： A61K31/403
摘要：
The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要（中）：
本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的稠合吲哚衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/403 | ....与碳环稠合的，例如咔唑 |