发明申请
WO2004105694A3 PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR ADMINISTRATION OF HYDROPHOBIC DRUGS
审中-公开
基本信息:
- 专利标题： PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR ADMINISTRATION OF HYDROPHOBIC DRUGS
- 申请号：PCT/US2004/016286 申请日：2004-05-24
- 公开(公告)号：WO2004105694A3 公开(公告)日：2004-12-09
- 发明人： CHEN, Feng-Jing , PATEL, Mahesh, V. , FIKSTAD, David, T. , ZHANG, Huiping , GILIYAR, Chandrashekar
- 申请人： LIPOCINE, INC. , CHEN, Feng-Jing , PATEL, Mahesh, V. , FIKSTAD, David, T. , ZHANG, Huiping , GILIYAR, Chandrashekar
- 申请人地址： 350 West 800 North, #314, SLC, UT 84103 US
- 专利权人： LIPOCINE, INC.,CHEN, Feng-Jing,PATEL, Mahesh, V.,FIKSTAD, David, T.,ZHANG, Huiping,GILIYAR, Chandrashekar
- 当前专利权人： LIPOCINE, INC.,CHEN, Feng-Jing,PATEL, Mahesh, V.,FIKSTAD, David, T.,ZHANG, Huiping,GILIYAR, Chandrashekar
- 当前专利权人地址： 350 West 800 North, #314, SLC, UT 84103 US
- 代理机构： WESTERN, M., Wayne et al.
- 优先权： US10/444,935 20030522
- 主分类号： A61K31/355
- IPC分类号： A61K31/355 ; A61K31/56 ; C07J53/00
摘要：
Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly steroids, are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid; a solubilizer, preferably a vitamin E substance; and a surfactant. The synergistic effect between the hydrophobic drug and the vitamin E substance results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharmaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/34 | ...有仅以1个氧作为环杂原子的五元环的，例如异山梨醇 |
| --------------A61K31/352 | ....与碳环稠合的，例如大麻酚、乙胺太林 |
| ----------------A61K31/353 | .....3,4二氢苯并吡喃，例如色满、儿茶素 |
| ------------------A61K31/355 | ......生育酚，例如维生素E |