发明申请
WO2004102193A3 DETECTION OF BIOCHEMICAL INTERACTIONS ON A BIOSENSOR USING TUNABLE FILTERS AND TUNABLE LASERS
审中-公开
基本信息:
- 专利标题: DETECTION OF BIOCHEMICAL INTERACTIONS ON A BIOSENSOR USING TUNABLE FILTERS AND TUNABLE LASERS
- 专利标题(中):使用TUNABLE过滤器和柔性激光检测生物传感器的生物化学相互作用
- 申请号:PCT/US2004014262 申请日:2004-05-07
- 公开(公告)号:WO2004102193A3 公开(公告)日:2005-03-24
- 发明人: CUNNINGHAM BRIAN T , LI PETER Y , CHANG-HASNAIN CONSTANCE , MATEUS CARLOS
- 申请人: SRU BIOSYSTEMS LLC , UNIV CALIFORNIA , CUNNINGHAM BRIAN T , LI PETER Y , CHANG-HASNAIN CONSTANCE , MATEUS CARLOS
- 专利权人: SRU BIOSYSTEMS LLC,UNIV CALIFORNIA,CUNNINGHAM BRIAN T,LI PETER Y,CHANG-HASNAIN CONSTANCE,MATEUS CARLOS
- 当前专利权人: SRU BIOSYSTEMS LLC,UNIV CALIFORNIA,CUNNINGHAM BRIAN T,LI PETER Y,CHANG-HASNAIN CONSTANCE,MATEUS CARLOS
- 优先权: US43401503 2003-05-08
- 主分类号: G01N21/00
- IPC分类号: G01N21/00 ; G01N21/39 ; G01N21/45 ; G01N21/75 ; G01N33/50 ; G01N33/53 ; G01N33/543
摘要:
An apparatus and method for detection of peak wavelength values of colorimetric resonant optical biosensors using tunable filters and tunable lasers is provided. Biomolecular interactions may be detected on a biosensor by directing collimated white light towards a surface of the biosensor. Molecular binding on the surface of the biosensor is indicated by a shift in the peak wavelength value of reflected or transmitted light from the biosensor, while an increase in the wavelength corresponds to an increase in molecular absorption. A tunable laser light source may generate the collimated white light and a tunable filter may receive the reflected or transmitted light and pass the light to a photodiode sensor. The photodiode sensor then quantifies an amount of the light reflected or transmitted through the tunable filter as a function of the tuning voltage of the tunable filter.
摘要(中):
提供了使用可调滤波器和可调谐激光器检测比色共振光学生物传感器的峰值波长值的装置和方法。 可以在生物传感器上通过将准直的白光指向生物传感器的表面来检测生物分子相互作用。 生物传感器表面上的分子结合由来自生物传感器的反射光或透射光的峰值波长值的偏移表示,而波长的增加对应于分子吸收的增加。 可调谐激光源可以产生准直的白光,并且可调滤光器可以接收反射或透射的光并将光传递到光电二极管传感器。 然后光电二极管传感器根据可调谐滤波器的调谐电压量化反射或透过可调谐滤波器的光量。
IPC结构图谱:
G | 物理 |
--G01 | 测量;测试 |
----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
------G01N21/00 | 利用光学手段,即利用红外光、可见光或紫外光来测试或分析材料 |