基本信息:
- 专利标题： CGRP RECEPTOR ANTAGONISTS
- 专利标题（中）：CGRP受体拮抗剂
- 申请号：PCT/US2004/011280 申请日：2004-04-09
- 公开(公告)号：WO2004092168A1 公开(公告)日：2004-10-28
- 发明人： BURGEY, Christopher, S. , DENG, Zhengwu, J , NGUYEN, Diem, N. , PAONE, Daniel, V. , SHAW, Anthony, W. , WILLIAMS, Theresa, M.
- 申请人： MERCK & CO., INC. , BURGEY, Christopher, S. , DENG, Zhengwu, J , NGUYEN, Diem, N. , PAONE, Daniel, V. , SHAW, Anthony, W. , WILLIAMS, Theresa, M.
- 申请人地址： 126 East Lincoln Avenue, Rahway, NJ 07065-0907 US
- 专利权人： MERCK & CO., INC.,BURGEY, Christopher, S.,DENG, Zhengwu, J,NGUYEN, Diem, N.,PAONE, Daniel, V.,SHAW, Anthony, W.,WILLIAMS, Theresa, M.
- 当前专利权人： MERCK & CO., INC.,BURGEY, Christopher, S.,DENG, Zhengwu, J,NGUYEN, Diem, N.,PAONE, Daniel, V.,SHAW, Anthony, W.,WILLIAMS, Theresa, M.
- 当前专利权人地址： 126 East Lincoln Avenue, Rahway, NJ 07065-0907 US
- 代理机构： MERCK & CO., INC.
- 优先权： US60/463,089 20030415; US60/510,352 20031010
- 主分类号： C07D471/04
- IPC分类号： C07D471/04
摘要：
The present invention is directed to compounds of formula (I): (where variables R 1 , R 2 and R 3 are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compouds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要（中）：
本发明涉及式（I）化合物：（其中变量R 1，R 2和R 3如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防疾病 其中涉及CGRP，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D471/00 | 在稠环系中含有氮原子作为仅有的杂环原子、其中至少1个环是含有1个氮原子的六元环的杂环化合物，C07D451/00至C07D463/00不包括的 |
| --------C07D471/02 | .在稠环系中含两个杂环 |
| ----------C07D471/04 | ..邻位稠环系 |