发明申请
WO2004019960A2 HERBAL EXTRACT COMPRISING A MIXTURE OF SAPONINS OBTAINED FROM SAPINDUS TRIFOLIATUS FOR ANTICONVULSANT ACTIVITY
审中-公开
基本信息:
- 专利标题: HERBAL EXTRACT COMPRISING A MIXTURE OF SAPONINS OBTAINED FROM SAPINDUS TRIFOLIATUS FOR ANTICONVULSANT ACTIVITY
- 专利标题(中):包含从SAPINDUS TRIFOLIATUS获得的锑酸盐混合物用于抗生素活性的草药提取物
- 申请号:PCT/IN2003/000289 申请日:2003-08-27
- 公开(公告)号:WO2004019960A2 公开(公告)日:2004-03-11
- 发明人: ARORA, Sudershan, Kumar , SRIVASTAVA, Vandita , ADDEPALLI, Veeranjaneyulu , NATESAN, Sridhar , GOEL, Rajan
- 申请人: LUPIN LTD. , ARORA, Sudershan, Kumar , SRIVASTAVA, Vandita , ADDEPALLI, Veeranjaneyulu , NATESAN, Sridhar , GOEL, Rajan
- 申请人地址: 159, CST Road, Kalina, Santacruz (E), 400 098 Mumbai IN
- 专利权人: LUPIN LTD.,ARORA, Sudershan, Kumar,SRIVASTAVA, Vandita,ADDEPALLI, Veeranjaneyulu,NATESAN, Sridhar,GOEL, Rajan
- 当前专利权人: LUPIN LTD.,ARORA, Sudershan, Kumar,SRIVASTAVA, Vandita,ADDEPALLI, Veeranjaneyulu,NATESAN, Sridhar,GOEL, Rajan
- 当前专利权人地址: 159, CST Road, Kalina, Santacruz (E), 400 098 Mumbai IN
- 代理机构: MAJUMDAR, S.
- 优先权: IN779/MUM/2002 20020828
- 主分类号: A61K35/00
- IPC分类号: A61K35/00
摘要:
A pharmaceutical composition comprising a herbal extract, comprising a mixture of saponins prepared from the pericarp of Sapindus trifoliatus , with binding affinities for the receptor sites viz . GABA-A agonist site, Glutamate-AMPA site, Glutamate-Kainate site, Glutamate-NMDA agonistic site, Glutamate-NMDA glycine (strychnine insensitive) site and Sodium channel (site 2). having major mediatory role in anticonvulsant activity. A process for preparation of the herbal extract; isolation of six pure compounds from the mixture of saponins in the aqueous extract; and a pharmaceutical composition comprising the said extract in combination with pharmaceutically acceptable additives. A method of prophylactic treatment of migraine through anticonvulsant activity of the composition by its administration through intranasal route.
摘要(中):
包含草药提取物的药物组合物,其包含由Sapindus trifoliatus的果皮制备的皂苷的混合物,对受体位点的结合亲和力。 GABA-A激动剂位点,谷氨酸-AMPA位点,谷氨酸 - 红藻酸盐位点,谷氨酸-N NMDA激动位点,谷氨酸-MNDA甘氨酸(士的宁不敏感)位点和钠通道(位点2)。 在抗惊厥活性中具有重要的介导作用。 制备草药提取物的方法 在水提取物中从皂甙混合物中分离出六种纯化合物; 以及包含所述提取物与药学上可接受的添加剂组合的药物组合物。 通过鼻内途径施用组合物的抗惊厥活性来预防性治疗偏头痛的方法。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K35/00 | 含有其有不明结构的原材料或其反应产物的医用配制品 |