发明申请
WO03050271A2 IN VITRO PRODUCTION OF DENDRITIC CELLS FROM CD14+ MONOCYTES, ESPECIALLY FOR THE PREPARATION OF SUSPENSION, MONOLAYER AND THREE-DIMENSIONAL CELL AND/OR TISSUE MODELS, AND USE OF THESE MODELS
审中-公开
基本信息:
- 专利标题： IN VITRO PRODUCTION OF DENDRITIC CELLS FROM CD14+ MONOCYTES, ESPECIALLY FOR THE PREPARATION OF SUSPENSION, MONOLAYER AND THREE-DIMENSIONAL CELL AND/OR TISSUE MODELS, AND USE OF THESE MODELS
- 专利标题（中）：在CD14 +单核细胞中生产细胞，特别是制备悬浮液，单层和三维细胞和/或组织模型，以及这些模型的使用
- 申请号：PCT/EP0214874 申请日：2002-12-10
- 公开(公告)号：WO03050271A2 公开(公告)日：2003-06-19
- 发明人： BECHETOILLE NICOLAS , ANDRE VALERIE , DEZUTTER-DAMBUYANT COLETTE , ORLY ISABELLE , SCHMITT DANIEL , PERRIER ERIC
- 申请人： COLETICA , INST NAT SANTE RECH MED , BECHETOILLE NICOLAS , ANDRE VALERIE , DEZUTTER-DAMBUYANT COLETTE , ORLY ISABELLE , SCHMITT DANIEL , PERRIER ERIC
- 专利权人： COLETICA,INST NAT SANTE RECH MED,BECHETOILLE NICOLAS,ANDRE VALERIE,DEZUTTER-DAMBUYANT COLETTE,ORLY ISABELLE,SCHMITT DANIEL,PERRIER ERIC
- 当前专利权人： COLETICA,INST NAT SANTE RECH MED,BECHETOILLE NICOLAS,ANDRE VALERIE,DEZUTTER-DAMBUYANT COLETTE,ORLY ISABELLE,SCHMITT DANIEL,PERRIER ERIC
- 优先权： FR0115942 2001-12-10
- 主分类号： A61K8/00
- IPC分类号： A61K8/00 ; A61K8/98 ; A61K35/14 ; A61K39/00 ; A61K47/32 ; A61K47/34 ; A61K47/36 ; A61K47/38 ; A61K47/42 ; A61K47/46 ; A61K48/00 ; A61P17/00 ; A61P17/16 ; A61P35/00 ; A61Q17/00 ; C12N5/071 ; C12N5/0784 ; C12N5/06
摘要：
The invention relates to the use of CD14+ monocytes for the production of dendritic cells. The invention comprises the use of CD14+ monocytes isolated from peripheral circulating blood for obtaining, by differentiation, at least one mixed population of Langerhans cells and interstitial dendritic cells, both Langerhans cells and interstitial dendritic cells being preconditioned and undifferentiated, and/or differentiated and immature, and/or mature, and/or interdigitated. The invention comprises their use in suspension, monolayer and three-dimensional cell and tissue models. The invention comprises the use of these cells and of these models as study models for the assessment of immunotoxicity/immunotolerance, for the development of cosmetic and pharmaceutical active principles and for the development and implementation of methods of cell and tissue therapy.
摘要（中）：
本发明涉及CD14 +单核细胞用于树突细胞产生的用途。 本发明包括使用分离自外周循环血液的CD14 +单核细胞通过分化获得至少一种朗格汉斯细胞和间质树突状细胞的混合群体，朗格汉斯细胞和间质树突状细胞都被预处理和未分化，和/或分化和未成熟 ，和/或成熟，和/或交叉。 本发明包括它们在悬浮液，单层和三维细胞和组织模型中的用途。 本发明包括使用这些细胞和这些模型作为用于评估免疫毒性/免疫耐受性的研究模型，用于开发化妆品和药物活性成分以及开发和实施细胞和组织治疗方法。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K8/00 | 化妆品或类似的梳妆用配制品 |