基本信息:
- 专利标题： HEMATOPOIETIC CELLS FROM HUMAN EMBRYONIC STEM CELLS
- 专利标题（中）：人胚胎干细胞的HEMATOPOIETIC细胞
- 申请号：PCT/US0239091 申请日：2002-12-06
- 公开(公告)号：WO03050251A2 公开(公告)日：2003-06-19
- 发明人： BHATIA MICKIE , MADRENAS JOAQUIN , FERBER IRIS A , MAJUMDAR ANISH SEN
- 申请人： GERON CORP , ROBARTS RES INST , BHATIA MICKIE , MADRENAS JOAQUIN , FERBER IRIS A , MAJUMDAR ANISH SEN
- 专利权人： GERON CORP,ROBARTS RES INST,BHATIA MICKIE,MADRENAS JOAQUIN,FERBER IRIS A,MAJUMDAR ANISH SEN
- 当前专利权人： GERON CORP,ROBARTS RES INST,BHATIA MICKIE,MADRENAS JOAQUIN,FERBER IRIS A,MAJUMDAR ANISH SEN
- 优先权： US33897901 2001-12-07
- 主分类号： C12N5/10
- IPC分类号： C12N5/10 ; A61K48/00 ; A61P7/00 ; A61P29/00 ; A61P35/00 ; A61P35/02 ; A61P37/02 ; A61P43/00 ; C12N5/078 ; C12N
摘要：
This invention provides a system for producing cells of the hematopoietic lineage from embryonic stem cells. Differentiation is conducted in the presence of hematogenic cytokines and other factors listed in the disclosure. The cell population that is obtained is remarkably enriched in CD45 +ve cells, a marker of early hematopoietic precursor with self-renewing capacity. Including a bone morphogenic protein during the differentiation process enhances the ability of the cell population to form secondary colonies. Because of the enormous replicative capacity of embryonic stem cells, this provides an important new commercial source of hematopoietic cells.
摘要（中）：
本发明提供了一种用于从胚胎干细胞产生造血谱系细胞的系统。 在本发明中列出的造血细胞因子和其它因素的存在下进行分化。 获得的细胞群显着丰富了CD45 + ve细胞，这是具有自我更新能力的早期造血前体的标志物。 在分化过程中包括骨形态发生蛋白增强了细胞群体形成第二集落的能力。 由于胚胎干细胞巨大的复制能力，这为造血细胞提供了重要的新商业来源。