基本信息:
- 专利标题： ANTIBODIES TO CD40
- 专利标题（中）：CD40抗体
- 申请号：PCT/US0236107 申请日：2002-11-08
- 公开(公告)号：WO03040170A9 公开(公告)日：2004-06-10
- 发明人： BEDIAN VAHE , GLADUE RONALD P , CORVALAN JOSE , JIA XIAO-CHI , FENG XIAO
- 申请人： PFIZER PROD INC , ABGENIX INC , BEDIAN VAHE , GLADUE RONALD P , CORVALAN JOSE , JIA XIAO-CHI , FENG XIAO
- 专利权人： PFIZER PROD INC,ABGENIX INC,BEDIAN VAHE,GLADUE RONALD P,CORVALAN JOSE,JIA XIAO-CHI,FENG XIAO
- 当前专利权人： PFIZER PROD INC,ABGENIX INC,BEDIAN VAHE,GLADUE RONALD P,CORVALAN JOSE,JIA XIAO-CHI,FENG XIAO
- 优先权： US34898001 2001-11-09
- 主分类号： A01H5/00
- IPC分类号： A01H5/00 ; A01K67/027 ; A61K31/7088 ; A61K35/76 ; A61K39/395 ; A61K48/00 ; A61P13/08 ; A61P13/10 ; A61P35/00 ; A61P35/02 ; A61P43/00 ; C07K20060101 ; C07K16/28 ; C07K16/40 ; C07K16/46 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/06 ; C12N5/10 ; C12N15/09 ; C12N15/12 ; C12P21/02 ; C12P21/08 ; C12N15/00 ; C12N15/11 ; C12N15/63
摘要：
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要（中）：
本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。 本发明还涉及人抗CD40抗体及其抗原结合部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物。
公开/授权文献:
- WO03040170A2 ANTIBODIES TO CD40 公开/授权日：2003-05-15
IPC结构图谱:
| A | 人类生活必需 |
| --A01 | 农业；林业；畜牧业；狩猎；诱捕；捕鱼 |
| ----A01H | 新植物或获得新植物的方法；通过组织培养技术的植物再生 |
| ------A01H5/00 | 有花植物，即被子植物 |