发明申请
WO2003030909A1 2- AND 4-AMINOPYRIMIDINES N-SUBSTTITUDED BY A BICYCLIC RING FOR USE AS KINASE INHIBITORS IN THE TREATMENT OF CANCER
审中-公开
基本信息:
- 专利标题： 2- AND 4-AMINOPYRIMIDINES N-SUBSTTITUDED BY A BICYCLIC RING FOR USE AS KINASE INHIBITORS IN THE TREATMENT OF CANCER
- 专利标题（中）：用于治疗癌症的双相环用作激酶抑制剂的2-和4-氨基亚氨基嘧啶
- 申请号：PCT/US2002/030616 申请日：2002-09-25
- 公开(公告)号：WO2003030909A1 公开(公告)日：2003-04-17
- 发明人： NAGARATHNAM, Dhanapalan , WANG, Chunguang , CHEN, Yuanwei , YI, Lin , CHEN, Jianqing , WEBER, Olaf , BOYER, Stephen , CLARK, Roger, B. , PHILLIPS, Barton , MEAHL, Jennifer , LADOUCEUR, Gaetan , BI, Cheng , BURKE, Michael, J. , COOK, James , VERMA, Sharad, K. , FAN, Jianmei
- 申请人： BAYER CORPORATION , NAGARATHNAM, Dhanapalan , WANG, Chunguang , CHEN, Yuanwei , YI, Lin , CHEN, Jianqing , WEBER, Olaf , BOYER, Stephen , CLARK, Roger, B. , PHILLIPS, Barton , MEAHL, Jennifer , LADOUCEUR, Gaetan , BI, Cheng , BURKE, Michael, J. , COOK, James , VERMA, Sharad, K. , FAN, Jianmei
- 申请人地址： 100 Bayer Road, Pittsburgh, PA 15205 US
- 专利权人： BAYER CORPORATION,NAGARATHNAM, Dhanapalan,WANG, Chunguang,CHEN, Yuanwei,YI, Lin,CHEN, Jianqing,WEBER, Olaf,BOYER, Stephen,CLARK, Roger, B.,PHILLIPS, Barton,MEAHL, Jennifer,LADOUCEUR, Gaetan,BI, Cheng,BURKE, Michael, J.,COOK, James,VERMA, Sharad, K.,FAN, Jianmei
- 当前专利权人： BAYER CORPORATION,NAGARATHNAM, Dhanapalan,WANG, Chunguang,CHEN, Yuanwei,YI, Lin,CHEN, Jianqing,WEBER, Olaf,BOYER, Stephen,CLARK, Roger, B.,PHILLIPS, Barton,MEAHL, Jennifer,LADOUCEUR, Gaetan,BI, Cheng,BURKE, Michael, J.,COOK, James,VERMA, Sharad, K.,FAN, Jianmei
- 当前专利权人地址： 100 Bayer Road, Pittsburgh, PA 15205 US
- 代理机构： GREENMAN, Jeffrey, M.
- 优先权： US60/324,276 20010925; US60/352,509 20020131
- 主分类号： A61K31/506
- IPC分类号： A61K31/506
摘要：
A coumpound of the formula (I) wherein each X is independently NR 1 R 6 , NR 4 R 5 , or R 4 , with the proviso that at least one X must be NR 1 R 6 ; each R 1 is independently an optionally substituted fused bicyclic unsaturated ring containing 9 or 10 atoms optionally containing 1-4 heteroatoms selected from the group consisting of N, S and O, and the variables R 2-6 are as defined in claim 1, are claimed. These compounds are kinase inhibitors useful in the treatment of cancer and viral infections.
摘要（中）：
式（I）的化合物，其中每个X独立地是NR 6，R 6，R 6，R 5， 或R 4，但条件是至少一个X必须是NR 6 R 6。 每个R 1独立地是含有9或10个原子的任选取代的稠合双环不饱和环，任选地含有1-4个选自N，S和O的杂原子，以及 如权利要求1中所定义的变量R 2-6是要求保护的。 这些化合物是可用于治疗癌症和病毒感染的激酶抑制剂。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/50 | ....哒嗪；氢化哒嗪 |
| ----------------A61K31/506 | .....未稠合的并且含有另外杂环的 |