基本信息:
- 专利标题： BICYCLIC HETEROCYCLES AS RXR LIGANDS
- 申请号：PCT/US2002/029298 申请日：2002-09-16
- 公开(公告)号：WO2003027090A3 公开(公告)日：2003-04-03
- 发明人： HAFFNER, Curt, Dale , KALDOR, Istvan , MCDOUGALD, Darryl, Lynn , MILLER, Aaron, Bayne
- 申请人： SMITHKLINE BEECHAM CORPORATION , HAFFNER, Curt, Dale , KALDOR, Istvan , MCDOUGALD, Darryl, Lynn , MILLER, Aaron, Bayne
- 申请人地址： One Franklin Plaza, Philadelphia, PA 19101 US
- 专利权人： SMITHKLINE BEECHAM CORPORATION,HAFFNER, Curt, Dale,KALDOR, Istvan,MCDOUGALD, Darryl, Lynn,MILLER, Aaron, Bayne
- 当前专利权人： SMITHKLINE BEECHAM CORPORATION,HAFFNER, Curt, Dale,KALDOR, Istvan,MCDOUGALD, Darryl, Lynn,MILLER, Aaron, Bayne
- 当前专利权人地址： One Franklin Plaza, Philadelphia, PA 19101 US
- 代理机构： LEVY, David, J.
- 优先权： US60/325,092 20010925
- 主分类号： C07D307/80
- IPC分类号： C07D307/80
摘要：
The present invention includes novel retinoid compounds that have selectivity as RXR agonists on one or more isoforms of RXR, currently, RXRα RXRβ, or RXRγ. The present compounds, an d ph armaceutical compositions incorporating these compounds, therefore, are effective in treating conditions mediated by RXRs. Among other physiological responses, the compounds of the present invention reduce blood glucose and maintain body weight, and, thus, are useful for the treatment of diabetes (NIDDIM) and obesity
公开/授权文献:
- WO2003027090A2 SELECTIVE RXR LIGANDS 公开/授权日：2003-04-03
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D307/00 | 杂环化合物，含五元环，含有1个氧原子作为仅有的杂环原子 |
| --------C07D307/02 | .不和其他环稠合 |
| ----------C07D307/78 | ..苯并 |
| ------------C07D307/79 | ...仅有氢原子、烃基或取代烃基，直接连在杂环的碳原子上 |
| --------------C07D307/80 | ....被氧原子取代的基 |