发明申请
WO2003012043A2 ENHANCING ORGAN MATURITY IN NEONATES AND PREDICTING THEIR DURATION OF INTENSIVE CARE
审中-公开
基本信息:
- 专利标题： ENHANCING ORGAN MATURITY IN NEONATES AND PREDICTING THEIR DURATION OF INTENSIVE CARE
- 专利标题（中）：增强有机成分，预测其强化护理时间
- 申请号：PCT/US2002/023983 申请日：2002-07-26
- 公开(公告)号：WO2003012043A2 公开(公告)日：2003-02-13
- 发明人： HANAUSKE-ABEL, Hartmut, M. , HANAUSKE, Axel-Rainer
- 申请人： HANAUSKE-ABEL, Hartmut, M. , HANAUSKE, Axel-Rainer
- 申请人地址： 1055 River Road, Apt. 510 South, Edge Water, NJ 07020 US
- 专利权人： HANAUSKE-ABEL, Hartmut, M.,HANAUSKE, Axel-Rainer
- 当前专利权人： HANAUSKE-ABEL, Hartmut, M.,HANAUSKE, Axel-Rainer
- 当前专利权人地址： 1055 River Road, Apt. 510 South, Edge Water, NJ 07020 US
- 代理机构： GOLDMAN, Michael, L.
- 优先权： US60/308,143 20010727
- 主分类号： C12N
- IPC分类号： C12N
摘要：
The present invention is directed to methods of enhancing organ maturity of premature human neonates or increasing collagen type IV formation in a living system by administering a growth factor, a gene encoding a growth factor, or an agent that increases growth factor formation to the living system under conditions effective to increase collagen type IV formation. Another aspect of the present invention relates to a method of predicting a premature human neonate's length of stay in a neonatal intensive care unit as well as the anticipated medical costs incurred during said stay by providing a sample from the premature human neonate and determining biomarkers derived from the extracellular matrix in the sample. The biomarker levels or ratios thereof in the sample are compared to a standard to ascertain the premature human neonate's length of stay in a neonatal intensive care unit as well as the anticipated medical costs incurred during said stay.
摘要（中）：
本发明涉及通过施用生长因子，编码生长因子的基因或将生长因子形成增加至生物体的药剂来增加早产新生儿的器官成熟或增加生物体系中的胶原IV型形成的方法 在有效增加胶原IV型形成的条件下。 本发明的另一方面涉及一种预测新生儿早产新生儿在新生儿重症监护病房中的停留时间的方法，以及通过提供来自早产的人新生儿的样品和确定来自 样品中的细胞外基质。 将样品中的生物标志物水平或比例与标准进行比较，以确定新生儿重症监护室中过早的新生儿停留时间以及在所述停留期间发生的预期医疗费用。