发明申请
WO2002099069A2 MODULATING NEURONAL OUTGROWTH VIA THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I (MHC I) MOLECULE
审中-公开
基本信息:
- 专利标题： MODULATING NEURONAL OUTGROWTH VIA THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I (MHC I) MOLECULE
- 专利标题（中）：通过主要合成复合物类I（MHC I）分子调节神经生长
- 申请号：PCT/US2002/017743 申请日：2002-06-05
- 公开(公告)号：WO2002099069A2 公开(公告)日：2002-12-12
- 发明人： KAUFMAN, Daniel, L. , HANSSEN, Lorraine , ZEKZER, Daniel
- 申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , KAUFMAN, Daniel, L. , HANSSEN, Lorraine , ZEKZER, Daniel
- 申请人地址： 1111 Franklin Street, 12th Floor, Oakland, CA 94607-5200 US
- 专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,KAUFMAN, Daniel, L.,HANSSEN, Lorraine,ZEKZER, Daniel
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,KAUFMAN, Daniel, L.,HANSSEN, Lorraine,ZEKZER, Daniel
- 当前专利权人地址： 1111 Franklin Street, 12th Floor, Oakland, CA 94607-5200 US
- 代理机构： HUNTINGTON, R., Danny
- 优先权： US60/295,596 20010605
- 主分类号： C12N
- IPC分类号： C12N
摘要：
The invention relates to methods and compositions for treating neural damage caused by injury or disease, by enhancing neural outgrowth and/or repair responses in the nervous system. Preferably, the methods and compositions utilize agents which interfere with the ability of the major histocompatibility complex (MHC) Class I molecule (MHC I) to inhibit neurite outgrowth. Such agents include antibodies directed to MHC I, MHC I fragments and/or analogs, and agents which interfere with MHC I interaction with its neuronal receptor and the receptor's signaling pathway.
摘要（中）：
本发明涉及通过增强神经系统中的神经生长和/或修复反应来治疗由损伤或疾病引起的神经损伤的方法和组合物。 优选地，所述方法和组合物利用干扰主要组织相容性复合体（MHC）I类分子（MHC I）抑制神经突生长的能力的试剂。 此类试剂包括针对MHC I，MHC I片段和/或类似物的抗体，以及干扰MHC I与神经元受体和受体信号通路相互作用的试剂。