发明申请
WO2002086075A3 METHODS AND COMPOSITION FOR THE PRODUCTION OF ORTHOGANAL TRNA-AMINOACYLTRNA SYNTHETASE PAIRS
审中-公开
基本信息:
- 专利标题： METHODS AND COMPOSITION FOR THE PRODUCTION OF ORTHOGANAL TRNA-AMINOACYLTRNA SYNTHETASE PAIRS
- 申请号：PCT/US2002/012635 申请日：2002-04-19
- 公开(公告)号：WO2002086075A3 公开(公告)日：2002-10-31
- 发明人： SCHULTZ, Peter , WANG, Lei , ANDERSON, John, Christopher , CHIN, Jason, W. , LIU, David, R. , MAGLIERY, Thomas, J. , MEGGERS, Eric, L. , MEHL, Ryan, Aaron , PASTRNAK, Miro , SANTORO, Stephen, William , ZHANG, Zhiwen
- 申请人： THE SCRIPPS RESEARCH INSTITUTE , SCHULTZ, Peter , WANG, Lei , ANDERSON, John, Christopher , CHIN, Jason, W. , LIU, David, R. , MAGLIERY, Thomas, J. , MEGGERS, Eric, L. , MEHL, Ryan, Aaron , PASTRNAK, Miro , SANTORO, Stephen, William , ZHANG, Zhiwen
- 申请人地址： 10550 North Torrey Pines Road, La Jolla, CA 92037 US
- 专利权人： THE SCRIPPS RESEARCH INSTITUTE,SCHULTZ, Peter,WANG, Lei,ANDERSON, John, Christopher,CHIN, Jason, W.,LIU, David, R.,MAGLIERY, Thomas, J.,MEGGERS, Eric, L.,MEHL, Ryan, Aaron,PASTRNAK, Miro,SANTORO, Stephen, William,ZHANG, Zhiwen
- 当前专利权人： THE SCRIPPS RESEARCH INSTITUTE,SCHULTZ, Peter,WANG, Lei,ANDERSON, John, Christopher,CHIN, Jason, W.,LIU, David, R.,MAGLIERY, Thomas, J.,MEGGERS, Eric, L.,MEHL, Ryan, Aaron,PASTRNAK, Miro,SANTORO, Stephen, William,ZHANG, Zhiwen
- 当前专利权人地址： 10550 North Torrey Pines Road, La Jolla, CA 92037 US
- 代理机构： QUINE, Jonathan, Alan
- 优先权： US60/285,030 200104019; US60/355,514 20020206
- 主分类号： C12N9/00
- IPC分类号： C12N9/00
摘要：
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.