发明申请
WO02072127A3 MODULATION OF SMOOTH MUSCLE CELL PROLIFERATION BY VEGF-X OR ANTAGONISTS THEREOF
审中-公开
基本信息:
- 专利标题： MODULATION OF SMOOTH MUSCLE CELL PROLIFERATION BY VEGF-X OR ANTAGONISTS THEREOF
- 专利标题（中）：通过VEGF-X或其拮抗剂调节平滑肌细胞增殖
- 申请号：PCT/EP0202616 申请日：2002-03-07
- 公开(公告)号：WO02072127A3 公开(公告)日：2003-09-04
- 发明人： GEESIN JEFFREY C , GOSIEWSKA ANNA , XU JEAN , GORDON ROBERT , YON JEFF , DHANARAJ SRIDEVI NAIDU , HARRIS IAN
- 申请人： JANSSEN PHARMACEUTICA NV , GEESIN JEFFREY C , GOSIEWSKA ANNA , XU JEAN , GORDON ROBERT , YON JEFF , DHANARAJ SRIDEVI NAIDU , HARRIS IAN
- 专利权人： JANSSEN PHARMACEUTICA NV,GEESIN JEFFREY C,GOSIEWSKA ANNA,XU JEAN,GORDON ROBERT,YON JEFF,DHANARAJ SRIDEVI NAIDU,HARRIS IAN
- 当前专利权人： JANSSEN PHARMACEUTICA NV,GEESIN JEFFREY C,GOSIEWSKA ANNA,XU JEAN,GORDON ROBERT,YON JEFF,DHANARAJ SRIDEVI NAIDU,HARRIS IAN
- 优先权： US27490101 2001-03-09
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61K35/76 ; A61K38/00 ; A61K38/19 ; A61K39/395 ; A61K45/00 ; A61K48/00 ; A61P9/00 ; A61P9/10 ; A61P13/00 ; A61P43/00 ; C12N5/06 ; C12N15/09 ; C12Q1/02 ; G01N33/15 ; G01N33/50 ; G01N33/68 ; A61K38/18 ; C12N15/11
摘要：
There is provided a novel use for vascular endothelial growth factor, herein designated VEGF-X, and a CUB domain present in the sequence of VEGF-X, which enhance smooth muscle cell proliferation and can be used to treat diseases associated with reduced smooth muscle cell proliferation. VEGF-X, and a CUB domain can also be used in tissue engineering applications to increase the number of smooth muscle cells within specific tissue to restore that tissue function or architecture. Screening methods for identifying inhibitors of VEGF-X biological activity are also disclosed and these inhibitors include neutralizing VEGF-X antibodies, antisense VEGF-X sequences or non-protein antagonists competing with VEGF-X biological activity. Also provided are therapeutic methods for treating disorders associated with smooth muscle cells hyperproliferation and methods of diagnosis a pathological condition or susceptibility to a pathological condition associated with smooth muscle cell hyperproliferation.
摘要（中）：
提供了VEGF-X序列中存在的血管内皮生长因子（称为VEGF-X）和CUB结构域的新型用途，其增强平滑肌细胞增殖并可用于治疗与减少的平滑肌细胞相关的疾病 增殖。 VEGF-X和CUB结构域也可用于组织工程应用中，以增加特定组织内的平滑肌细胞的数量以恢复组织功能或结构。 还公开了用于鉴定VEGF-X生物活性抑制剂的筛选方法，并且这些抑制剂包括与VEGF-X生物活性竞争的中和VEGF-X抗体，反义VEGF-X序列或非蛋白质拮抗剂。 还提供了用于治疗与平滑肌细胞过度增生相关的疾病的治疗方法以及诊断与平滑肌细胞过度增殖相关的病理状况的病理状况或易感性的方法。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/70 | .碳水化合物；糖；其衍生物 |
| ----------A61K31/7088 | ..含有3个或更多个核苷或核苷酸的化合物 |