发明申请
WO02069198A2 HLA LIGAND DATABASE UTILIZING PREDICTIVE ALGORITHMS AND METHODS OF MAKING AND USING SAME
审中-公开
基本信息:
- 专利标题： HLA LIGAND DATABASE UTILIZING PREDICTIVE ALGORITHMS AND METHODS OF MAKING AND USING SAME
- 专利标题（中）：使用预测算法的HLA LIGAND数据库及其制作和使用方法
- 申请号：PCT/US0205298 申请日：2002-02-21
- 公开(公告)号：WO02069198A2 公开(公告)日：2002-09-06
- 发明人： HILDEBRAND WILLIAM H , PRILLIMAN KILEY RAE , HICKMAN HEATHER D
- 申请人： HILDEBRAND WILLIAM H , PRILLIMAN KILEY RAE , HICKMAN HEATHER D
- 专利权人： HILDEBRAND WILLIAM H,PRILLIMAN KILEY RAE,HICKMAN HEATHER D
- 当前专利权人： HILDEBRAND WILLIAM H,PRILLIMAN KILEY RAE,HICKMAN HEATHER D
- 优先权： US97436601 2001-10-10; US27035701 2001-02-21; US2206601 2001-12-18
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K39/385 ; A61K39/39 ; A61K47/48 ; C07K14/16 ; C07K14/47 ; C07K14/705 ; C07K14/74 ; C07K14/78 ; C12N9/12 ; C12N9/64 ; G01N33/50 ; G06F17/30
摘要：
The present invention generally relates to a MHC ligand database populated with MHC ligand sequences, motifs extended motifs, subm otifs, ligands unique to infected cells, tumor specific ligands, as well as a collection of current and future developed MHC lignad sequences developed by alternative methods. Other than the ligand sequences developed by alternative methods (which are in many cases non-standarized), the remaining ligand sequences are obtained in a standardized and minimum-variable dependent manner from soluble HLA molecules constructed according to the methodology described herein. The present invention further includes methodologies incorporating linear and predicitve algorithm searching and comparison utilities.
摘要（中）：
本发明一般涉及一种MHC配体数据库，其中包含MHC配体序列，基序扩展基序，亚基，感染细胞独特的配体，肿瘤特异性配体，以及通过替代方法开发的当前和未来开发的MHC木质素序列的集合 。 除了通过替代方法（在许多情况下是非标准化）开发的配体序列之外，剩余的配体序列以标准化和最小可变的依赖方式从根据本文所述的方法构建的可溶性HLA分子获得。 本发明还包括结合线性和预测算法搜索和比较实用程序的方法。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/127 | ..脂质体 |