发明申请
WO2002042272A3 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDINES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE
审中-公开
基本信息:
- 专利标题： SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDINES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE
- 申请号：PCT/US2001/043280 申请日：2001-11-20
- 公开(公告)号：WO2002042272A3 公开(公告)日：2002-05-30
- 发明人： SOUTH, Michael, S. , CASE, Brenda , GARLAND, Danny, J. , HAYES, Michael, J. , HUANG, Horng-Chih , HUANG, Wei , JONES, Darin, E. , NEUMANN, William, L. , PARLOW, John, J. , REITZ, David, B. , RUEPPEL, Melvin, L. , WEBBER, Ronald, K.
- 申请人： PHARMACIA CORPORATION , SOUTH, Michael, S. , CASE, Brenda , GARLAND, Danny, J. , HAYES, Michael, J. , HUANG, Horng-Chih , HUANG, Wei , JONES, Darin, E. , NEUMANN, William, L. , PARLOW, John, J. , REITZ, David, B. , RUEPPEL, Melvin, L. , WEBBER, Ronald, K.
- 申请人地址： Global Patent Department, 800 North Lindbergh Boulevard, St. Louis, MO 63167 US
- 专利权人： PHARMACIA CORPORATION,SOUTH, Michael, S.,CASE, Brenda,GARLAND, Danny, J.,HAYES, Michael, J.,HUANG, Horng-Chih,HUANG, Wei,JONES, Darin, E.,NEUMANN, William, L.,PARLOW, John, J.,REITZ, David, B.,RUEPPEL, Melvin, L.,WEBBER, Ronald, K.
- 当前专利权人： PHARMACIA CORPORATION,SOUTH, Michael, S.,CASE, Brenda,GARLAND, Danny, J.,HAYES, Michael, J.,HUANG, Horng-Chih,HUANG, Wei,JONES, Darin, E.,NEUMANN, William, L.,PARLOW, John, J.,REITZ, David, B.,RUEPPEL, Melvin, L.,WEBBER, Ronald, K.
- 当前专利权人地址： Global Patent Department, 800 North Lindbergh Boulevard, St. Louis, MO 63167 US
- 代理机构： DOTY, Kathryn, J.
- 优先权： US60/252,158 200011020; US60/350,069 20011107
- 主分类号： A61K31/4418
- IPC分类号： A61K31/4418
摘要：
The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/44 | ....非稠合的吡啶；其氢化的衍生物 |
| ----------------A61K31/4418 | .....含有直接与杂环相连的碳环的，例如赛庚啶 |