基本信息:
- 专利标题： NUCLEOTIDE SEQUENCES FOR GENE REGULATION AND METHODS OF USE THEREOF
- 专利标题（中）：用于基因调控的核苷酸序列及其使用方法
- 申请号：PCT/US2000/015728 申请日：2000-06-06
- 公开(公告)号：WO00075279A2 公开(公告)日：2000-12-14
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/7088 ; A61K38/00 ; A61K39/395 ; A61K48/00 ; A61P1/16 ; A61P3/10 ; A61P7/02 ; A61P9/10 ; A61P19/02 ; A61P19/10 ; A61P25/16 ; A61P25/28 ; A61P35/00 ; C07K14/47 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N9/64 ; C12N
摘要：
The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest in an age-related manner and/or in a liver-specific manner. The invention further provides methods of using the regulatory nucleic acid sequences provided herein for age-related and/or liver-specific expression of nucleotides sequences of interest. The invention also provides host cells and transgenic non-human animals which harbor the regulatory nucleic acid sequences of the invention. The compositions and methods of the invention are useful in regulating expression of a nucleotide sequence of interest in an age-related and/or liver-specific manner.
摘要（中）：
本发明提供调节目的核苷酸序列表达的核酸序列。 特别地，本发明提供了以年龄相关的方式和/或肝特异性方式调节目的核苷酸序列的表达的核酸序列。 本发明进一步提供使用本文提供的调节性核酸序列用于感兴趣的核苷酸序列的年龄相关和/或肝特异性表达的方法。 本发明还提供了携带本发明的调节性核酸序列的宿主细胞和转基因非人动物。 本发明的组合物和方法可用于调节年龄相关和/或肝特异性方式的感兴趣的核苷酸序列的表达。