A system and method for eluting one or more radioisotope processing elements, such as generators and/or concentration and purification components, with a gas over eluent delivery mechanism is disclosed. The system is adapted to an elution/concentration system using two such mechanisms, one for an initial elution of one or more generators, and a second for "re-elution" of concentrated and purified radioisotope contained in a concentration subsystem. The operation of such a dual mechanism system may also be completely or partially automated. The invention also discloses a concentration subsystem containing all single-use components needed for concentration and/or purification, as a single use, self sealed, cartridge that can safely store waste eluate for safe and simple disposal.