基本信息:
- 专利标题: A METHOD OF TREATING TUMORS USING FAS-INDUCED APOPTOSIS
- 专利标题(英):A method of treating tumors using fas-induced apoptosis
- 专利标题(中):肿瘤治疗技术使用FAS诱导的细胞凋亡
- 申请号:PCT/US1999/026221 申请日:1999-11-05
- 公开(公告)号:WO00027883A2 公开(公告)日:2000-05-18
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; A61K35/76 ; A61K38/00 ; A61K48/00 ; A61P35/00 ; C07K14/705 ; C12N5/10 ; C12N15/62 ; C12N15/861 ; C12N15/86
摘要:
The present invention provides a method of killing a Fas tumor cell comprising introducing into a second tumor cell a nucleic acid encoding a Fas ligand (FasL), whereby the second tumor cell expresses the nucleic acid thereby producing FasL, and whereby interaction of the Fas tumor cell with the second tumor cell expressing FasL causes the Fas tumor cell to undergo apoptosis, thereby killing the Fas tumor cell.
摘要(中):
本发明涉及Fas +肿瘤细胞杀伤技术,其包括向第二肿瘤细胞中导入编码Fas配体(FasL)的核酸。 第二肿瘤细胞表达由此产生FasL和Fas +肿瘤细胞与表达第二FasL的肿瘤细胞的相互作用的核酸触发Fas +肿瘤细胞的细胞凋亡,由此破坏该细胞。