发明申请
WO00015655A1 PROCESS FOR PRODUCING PEPTIDES FROM BIOLOGICAL FLUIDS AND PEPTIDES OBTAINABLE BY SAID PROCESS
审中-公开
基本信息:
- 专利标题： PROCESS FOR PRODUCING PEPTIDES FROM BIOLOGICAL FLUIDS AND PEPTIDES OBTAINABLE BY SAID PROCESS
- 专利标题（英）：Process for producing peptides from biological fluids and peptides obtainable by said process
- 专利标题（中）：从生物流体生产肽的方法和通过合适的方法获得的肽
- 申请号：PCT/EP1999/007002 申请日：1999-09-15
- 公开(公告)号：WO00015655A1 公开(公告)日：2000-03-23
- 主分类号： C12P21/06
- IPC分类号： C12P21/06 ; A61K38/00 ; A61K38/01 ; A61K38/10 ; A61P31/00 ; A61P31/12 ; A61P35/00 ; C07K1/12 ; C07K1/16 ; C07K1/18 ; C07K1/20 ; C07K1/22 ; C07K7/06 ; C07K7/08 ; C07K14/315 ; C07K14/47 ; C07K14/79
摘要：
A process is provided for the production of at least one peptide of interest from a biological fluid comprising one or more proteins which contain the amino acid sequence of said peptide, wherein said fluid is contacted with a chromatographic medium to adsorb said protein including the peptide domain, the adsorbed material is hydrolysed to produce said peptide, the medium is washed to remove unbound material, the peptide is desorbed from the chromatographic medium and, optionally, further purified. Preferably, a chromatographic membrane is used and the hydrolysis is preferably carried out enzymatically. Also claimed are peptides, preferably with a biological activity, which are obtainable by the present process.
摘要（中）：
提供了用于从包含一种或多种含有所述肽的氨基酸序列的蛋白质的生物流体生产至少一种目的肽的方法，其中所述流体与色谱介质接触以吸附所述蛋白质，包括肽结构域 ，吸附的材料被水解以产生所述肽，洗涤介质以除去未结合的物质，肽从色谱介质解吸，并且任选进一步纯化。 优选地，使用色谱膜，并且优选在酶促下进行水解。 还要求的是优选具有生物活性的肽，其可通过本方法获得。
IPC结构图谱:
| C | 化学；冶金 |
| --C12 | 生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程 |
| ----C12P | 发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体 |
| ------C12P21/00 | 肽或蛋白质的制备 |
| --------C12P21/06 | .由肽键水解产生，如水解产物 |